273738

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3725975..3726594 Replicon chromosome
Accession NZ_CP119076
Organism Klebsiella aerogenes strain RX7.1

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag PYR66_RS17685 Protein ID WP_015367918.1
Coordinates 3726376..3726594 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag PYR66_RS17680 Protein ID WP_275047287.1
Coordinates 3725975..3726349 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYR66_RS17670 (PYR66_17670) 3721158..3722357 + 1200 WP_275047285.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PYR66_RS17675 (PYR66_17675) 3722380..3725526 + 3147 WP_275047286.1 multidrug efflux RND transporter permease subunit AcrB -
PYR66_RS17680 (PYR66_17680) 3725975..3726349 + 375 WP_275047287.1 Hha toxicity modulator TomB Antitoxin
PYR66_RS17685 (PYR66_17685) 3726376..3726594 + 219 WP_015367918.1 HHA domain-containing protein Toxin
PYR66_RS17690 (PYR66_17690) 3726728..3727291 + 564 WP_275047288.1 maltose O-acetyltransferase -
PYR66_RS17695 (PYR66_17695) 3727417..3727884 + 468 WP_275047289.1 YlaC family protein -
PYR66_RS17700 (PYR66_17700) 3727862..3729313 - 1452 WP_275050363.1 PLP-dependent aminotransferase family protein -
PYR66_RS17705 (PYR66_17705) 3729415..3730125 + 711 WP_275047290.1 GNAT family protein -
PYR66_RS17710 (PYR66_17710) 3730122..3730262 - 141 WP_275047291.1 type B 50S ribosomal protein L36 -
PYR66_RS17715 (PYR66_17715) 3730265..3730525 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T273738 WP_015367918.1 NZ_CP119076:3726376-3726594 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14421.18 Da        Isoelectric Point: 4.9045

>AT273738 WP_275047287.1 NZ_CP119076:3725975-3726349 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQINELIEHIATFALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVSASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure

References