273737

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2488803..2490373 Replicon chromosome
Accession NZ_CP119076
Organism Klebsiella aerogenes strain RX7.1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PYR66_RS11940 Protein ID WP_275046297.1
Coordinates 2488803..2490116 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PYR66_RS11945 Protein ID WP_275050308.1
Coordinates 2490116..2490373 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYR66_RS11915 (PYR66_11910) 2484215..2485552 + 1338 WP_275046292.1 glycoside hydrolase family 10 protein -
PYR66_RS11920 (PYR66_11915) 2485703..2486275 + 573 WP_275046293.1 peroxiredoxin -
PYR66_RS11925 (PYR66_11920) 2486291..2487523 + 1233 WP_275046294.1 thioredoxin family protein -
PYR66_RS11930 (PYR66_11925) 2487543..2488097 + 555 WP_275046295.1 sigma-70 family RNA polymerase sigma factor -
PYR66_RS11935 (PYR66_11930) 2488084..2488713 + 630 WP_275046296.1 NrsF family protein -
PYR66_RS11940 (PYR66_11935) 2488803..2490116 - 1314 WP_275046297.1 type II toxin-antitoxin system HipA family toxin Toxin
PYR66_RS11945 (PYR66_11940) 2490116..2490373 - 258 WP_275050308.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PYR66_RS11950 (PYR66_11945) 2490555..2491115 - 561 WP_275050309.1 RNA polymerase sigma factor -
PYR66_RS11955 (PYR66_11950) 2491121..2491546 - 426 WP_275046298.1 hypothetical protein -
PYR66_RS11960 (PYR66_11955) 2491724..2492743 + 1020 WP_275046299.1 helix-turn-helix domain-containing protein -
PYR66_RS11965 (PYR66_11960) 2492771..2494150 - 1380 WP_275046300.1 MFS transporter -
PYR66_RS11970 (PYR66_11965) 2494189..2495099 - 911 Protein_2342 aromatic amino acid DMT transporter YddG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-61)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48906.26 Da        Isoelectric Point: 7.5986

>T273737 WP_275046297.1 NZ_CP119076:c2490116-2488803 [Klebsiella aerogenes]
MAALSTWMNDELVGTLTKQANGAHTFRYAEAWLLNPRARPLSLSLPLQFGNITSDAVFNYFDNLLPDSVKVRERIVKRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPESEQPILGHLAWDSLDEKRLQTLLTAYQSDIPLGMIAGHDDFRISVAGAQEKTAL
LKIDGIWSIPKGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLTLARVLGFKVPDAEIIRTPDIRALAVARFDRRW
ARDNTVLLRLPQEDLCQTFGLPSSMKYESDGGPGIHEVMNFLLGSSEALTDRYDFMKFNVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDILSAFPVLGGTGLHLRDLKLSMSLKASKGRKVDINTLYPRHFLATAKEVNFPQDQMQEILRFFAENIP
SALETALARLPHDFSPAVYRSVTTHTLKLHARLMASL

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9531.92 Da        Isoelectric Point: 9.8682

>AT273737 WP_275050308.1 NZ_CP119076:c2490373-2490116 [Klebsiella aerogenes]
MIYSPVQLANHLKLVRQKNQWTQSDLARRIGIKQATISNFENHPEKTTLATVFKILQSLELVMSLSAKGESTAPAAGNPQ
QDLEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References