Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1887851..1888653 Replicon chromosome
Accession NZ_CP119047
Organism Staphylococcus epidermidis strain N2

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PZB81_RS09030 Protein ID WP_002493409.1
Coordinates 1888192..1888653 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag PZB81_RS09025 Protein ID WP_002493408.1
Coordinates 1887851..1888180 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZB81_RS08990 (PZB81_08990) 1883742..1885694 - 1953 WP_002493404.1 AAA family ATPase -
PZB81_RS08995 (PZB81_08995) 1885763..1885939 - 177 WP_002493405.1 hypothetical protein -
PZB81_RS09000 (PZB81_09000) 1886005..1886214 - 210 WP_001830281.1 hypothetical protein -
PZB81_RS09005 (PZB81_09005) 1886227..1886946 - 720 WP_002493406.1 phage repressor protein -
PZB81_RS09010 (PZB81_09010) 1886996..1887235 + 240 WP_002475580.1 hypothetical protein -
PZB81_RS09015 (PZB81_09015) 1887225..1887404 - 180 WP_002475588.1 hypothetical protein -
PZB81_RS09020 (PZB81_09020) 1887418..1887657 - 240 WP_002493407.1 helix-turn-helix transcriptional regulator -
PZB81_RS09025 (PZB81_09025) 1887851..1888180 + 330 WP_002493408.1 helix-turn-helix transcriptional regulator Antitoxin
PZB81_RS09030 (PZB81_09030) 1888192..1888653 + 462 WP_002493409.1 ImmA/IrrE family metallo-endopeptidase Toxin
PZB81_RS09035 (PZB81_09035) 1888883..1889191 + 309 WP_002493410.1 hypothetical protein -
PZB81_RS09040 (PZB81_09040) 1889193..1889774 + 582 WP_002493411.1 hypothetical protein -
PZB81_RS09045 (PZB81_09045) 1889837..1890886 + 1050 WP_002493412.1 site-specific integrase -
PZB81_RS09060 (PZB81_09060) 1891288..1891863 - 576 WP_002493413.1 competence protein ComK -
PZB81_RS09065 (PZB81_09065) 1892078..1892296 + 219 WP_001829292.1 IDEAL domain-containing protein -
PZB81_RS09070 (PZB81_09070) 1892374..1893360 - 987 WP_002493414.1 lipoate--protein ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1845104..1890886 45782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(28-120)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18183.68 Da        Isoelectric Point: 5.9380

>T273729 WP_002493409.1 NZ_CP119047:1888192-1888653 [Staphylococcus epidermidis]
MGLYEEICIDNDMVEIKETNKLPSFQSGFYMNGTVYIKSDLSEKEKIKVLYEELAHHKLTYGNILDQSKFNNRKFENYAR
RHGYEAALPLRIIVEAHNYGVSNLYELAEYVQLSEEYIAEILKHYKNKYGIGTHYEEYLITFDPLRVFKYKEI

Download         Length: 462 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12667.26 Da        Isoelectric Point: 4.9783

>AT273729 WP_002493408.1 NZ_CP119047:1887851-1888180 [Staphylococcus epidermidis]
MRTNDEIITIIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFANALHISTEYLLGFNGSEQTRQQDTM
AAHFDKEGLTEEEIEEVNKFIEWVKNRDK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References