Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 822537..823066 Replicon chromosome
Accession NZ_CP119047
Organism Staphylococcus epidermidis strain N2

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag PZB81_RS03845 Protein ID WP_001829891.1
Coordinates 822704..823066 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag PZB81_RS03840 Protein ID WP_001829931.1
Coordinates 822537..822707 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZB81_RS03815 (PZB81_03815) 818340..818819 + 480 WP_002494210.1 PH domain-containing protein -
PZB81_RS03820 (PZB81_03820) 818812..820338 + 1527 WP_275113494.1 PH domain-containing protein -
PZB81_RS03825 (PZB81_03825) 820325..820834 + 510 WP_002494208.1 PH domain-containing protein -
PZB81_RS03830 (PZB81_03830) 820882..821235 + 354 WP_001829915.1 holo-ACP synthase -
PZB81_RS03835 (PZB81_03835) 821302..822450 + 1149 WP_002494207.1 alanine racemase -
PZB81_RS03840 (PZB81_03840) 822537..822707 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PZB81_RS03845 (PZB81_03845) 822704..823066 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PZB81_RS03850 (PZB81_03850) 823411..824412 + 1002 WP_002494206.1 PP2C family protein-serine/threonine phosphatase -
PZB81_RS03855 (PZB81_03855) 824512..824838 + 327 WP_001829952.1 anti-sigma factor antagonist -
PZB81_RS03860 (PZB81_03860) 824840..825319 + 480 WP_002474646.1 anti-sigma B factor RsbW -
PZB81_RS03865 (PZB81_03865) 825294..826064 + 771 WP_002474636.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T273727 WP_001829891.1 NZ_CP119047:822704-823066 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT273727 WP_001829931.1 NZ_CP119047:822537-822707 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References