Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 811297..811806 Replicon chromosome
Accession NZ_CP119047
Organism Staphylococcus epidermidis strain N2

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag PZB81_RS03785 Protein ID WP_002494211.1
Coordinates 811603..811806 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag PZB81_RS03780 Protein ID WP_001829893.1
Coordinates 811297..811590 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZB81_RS03755 (PZB81_03755) 806305..807093 + 789 WP_002494215.1 hydroxyethylthiazole kinase -
PZB81_RS03760 (PZB81_03760) 807099..807737 + 639 WP_032603839.1 thiamine phosphate synthase -
PZB81_RS03765 (PZB81_03765) 807826..808698 + 873 WP_002458703.1 membrane protein insertase YidC -
PZB81_RS03770 (PZB81_03770) 808804..809457 - 654 WP_002494213.1 HD domain-containing protein -
PZB81_RS03775 (PZB81_03775) 809639..811123 - 1485 WP_002494212.1 cardiolipin synthase -
PZB81_RS03780 (PZB81_03780) 811297..811590 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
PZB81_RS03785 (PZB81_03785) 811603..811806 + 204 WP_002494211.1 hypothetical protein Toxin
PZB81_RS03790 (PZB81_03790) 811949..812086 + 138 WP_001829949.1 Lmo0850 family protein -
PZB81_RS03795 (PZB81_03795) 812185..813396 - 1212 WP_002474606.1 FtsW/RodA/SpoVE family cell cycle protein -
PZB81_RS03800 (PZB81_03800) 813787..814860 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
PZB81_RS03805 (PZB81_03805) 814872..816227 + 1356 WP_002494890.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7785.00 Da        Isoelectric Point: 6.4524

>T273726 WP_002494211.1 NZ_CP119047:811603-811806 [Staphylococcus epidermidis]
MKKGLIHVSGIKTTEQAKQLKDHLSKMIGINCVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 204 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT273726 WP_001829893.1 NZ_CP119047:811297-811590 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References