Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5094387..5096068 Replicon chromosome
Accession NZ_CP119013
Organism Klebsiella pneumoniae strain CR-hvKP005

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag PY729_RS25295 Protein ID WP_002885155.1
Coordinates 5094387..5095304 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag PY729_RS25300 Protein ID WP_004151732.1
Coordinates 5095310..5096068 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY729_RS25275 (PY729_25275) 5089693..5091213 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
PY729_RS25280 (PY729_25280) 5091210..5092208 + 999 WP_002885172.1 ribose ABC transporter permease -
PY729_RS25285 (PY729_25285) 5092239..5093180 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
PY729_RS25290 (PY729_25290) 5093255..5094262 + 1008 WP_004151731.1 carbohydrate kinase family protein -
PY729_RS25295 (PY729_25295) 5094387..5095304 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PY729_RS25300 (PY729_25300) 5095310..5096068 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
PY729_RS25305 (PY729_25305) 5096154..5096882 - 729 WP_002885152.1 response regulator transcription factor -
PY729_RS25310 (PY729_25310) 5097155..5099302 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
PY729_RS25315 (PY729_25315) 5099532..5100218 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T273718 WP_002885155.1 NZ_CP119013:c5095304-5094387 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT273718 WP_004151732.1 NZ_CP119013:c5096068-5095310 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References