Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2764606..2766194 Replicon chromosome
Accession NZ_CP119013
Organism Klebsiella pneumoniae strain CR-hvKP005

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag PY729_RS13705 Protein ID WP_004199851.1
Coordinates 2764606..2765928 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag PY729_RS13710 Protein ID WP_002904790.1
Coordinates 2765928..2766194 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY729_RS13690 (PY729_13690) 2759671..2762172 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
PY729_RS13695 (PY729_13695) 2762160..2763164 + 1005 WP_004199852.1 fimbrial protein -
PY729_RS13700 (PY729_13700) 2763297..2764589 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
PY729_RS13705 (PY729_13705) 2764606..2765928 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
PY729_RS13710 (PY729_13710) 2765928..2766194 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PY729_RS13715 (PY729_13715) 2766460..2766786 - 327 WP_002904788.1 hydroxyisourate hydrolase -
PY729_RS13720 (PY729_13720) 2766783..2767283 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PY729_RS13725 (PY729_13725) 2767261..2768640 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
PY729_RS13730 (PY729_13730) 2768986..2770140 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
PY729_RS13735 (PY729_13735) 2770121..2771044 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T273714 WP_004199851.1 NZ_CP119013:c2765928-2764606 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT273714 WP_002904790.1 NZ_CP119013:c2766194-2765928 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References