Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 934..1405 Replicon plasmid pK521-NR1
Accession NZ_CP118995
Organism Aeromonas media strain K521

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PYU99_RS21590 Protein ID WP_270824985.1
Coordinates 934..1197 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A428V512
Locus tag PYU99_RS21595 Protein ID WP_068979446.1
Coordinates 1181..1405 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYU99_RS21585 (PYU99_21585) 375..905 - 531 WP_083221094.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
PYU99_RS21590 (PYU99_21590) 934..1197 - 264 WP_270824985.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PYU99_RS21595 (PYU99_21595) 1181..1405 - 225 WP_068979446.1 DUF6290 family protein Antitoxin
PYU99_RS21600 (PYU99_21600) 1500..2342 - 843 Protein_4 Tn3 family transposase -
PYU99_RS21605 (PYU99_21605) 2479..4056 + 1578 WP_275124726.1 PAS domain-containing methyl-accepting chemotaxis protein -
PYU99_RS21610 (PYU99_21610) 4526..4813 - 288 WP_068979444.1 hypothetical protein -
PYU99_RS21615 (PYU99_21615) 4913..5221 - 309 WP_270824986.1 mobilization protein -
PYU99_RS21620 (PYU99_21620) 5222..5758 - 537 WP_068979442.1 DUF1640 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8310 8310
- flank IS/Tn - - 1500..2300 800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Relaxosome protein TraY

(4-47)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10302.01 Da        Isoelectric Point: 10.1953

>T273705 WP_270824985.1 NZ_CP118995:c1197-934 [Aeromonas media]
MAWKVELTDTAKKQLARLDKTQAQRITKYLRRVMLLEDPRDAGKALTGNLRTYWRYRVGDYRVVCEIRDNEMIIVAVMVG
HRSNIYE

Download         Length: 264 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8704.85 Da        Isoelectric Point: 4.3640

>AT273705 WP_068979446.1 NZ_CP118995:c1405-1181 [Aeromonas media]
MLAIRLPSDIEERLANLAQETGRTKTFYAREAILTHLEEMEDYYLAERVMEKVRKGEERLFSLDDVERDLGLES

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A428V512

References