273702

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 23712..24259 Replicon plasmid pK520-TEM
Accession NZ_CP118992
Organism Aeromonas allosaccharophila strain K520

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag PYU98_RS25650 Protein ID WP_134997959.1
Coordinates 23951..24259 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag PYU98_RS25645 Protein ID WP_134997958.1
Coordinates 23712..23951 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYU98_RS25625 (PYU98_25625) 20720..21157 - 438 WP_244776905.1 hypothetical protein -
PYU98_RS25630 (PYU98_25630) 21241..21888 - 648 WP_270796700.1 DUF2914 domain-containing protein -
PYU98_RS25635 (PYU98_25635) 22793..23242 + 450 WP_275058455.1 tetratricopeptide repeat protein -
PYU98_RS25640 (PYU98_25640) 23386..23655 + 270 WP_270796694.1 hypothetical protein -
PYU98_RS25645 (PYU98_25645) 23712..23951 + 240 WP_134997958.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PYU98_RS25650 (PYU98_25650) 23951..24259 + 309 WP_134997959.1 CcdB family protein Toxin
PYU98_RS25655 (PYU98_25655) 24407..24901 + 495 Protein_27 replication initiation protein -
PYU98_RS25660 (PYU98_25660) 25043..25552 + 510 Protein_28 TetR/AcrR family transcriptional regulator -
PYU98_RS25665 (PYU98_25665) 25564..26157 + 594 Protein_29 Tn3 family transposase -
PYU98_RS25670 (PYU98_25670) 26195..26362 + 168 WP_275058456.1 hypothetical protein -
PYU98_RS25675 (PYU98_25675) 26492..27133 + 642 WP_033147139.1 AAA family ATPase -
PYU98_RS25680 (PYU98_25680) 27172..27456 + 285 WP_033147140.1 hypothetical protein -
PYU98_RS25685 (PYU98_25685) 27679..28143 + 465 Protein_33 replication protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1C - 1..73881 73881
- flank IS/Tn - - 25582..26157 575


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11431.30 Da        Isoelectric Point: 4.6920

>T273702 WP_134997959.1 NZ_CP118992:23951-24259 [Aeromonas allosaccharophila]
MQFTIYRNKGNARAYPYLLDVQSDIIGELATRMVIPLFPLVAFTGRPAQRLNPVIIVEGDKYLVMTQDMAAVRLAQLGDE
VTGVQESRQLIKDAIDFLFDGV

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8659.76 Da        Isoelectric Point: 7.0125

>AT273702 WP_134997958.1 NZ_CP118992:23712-23951 [Aeromonas allosaccharophila]
MVAAAMRSKRTVSVTLEPSLLERARAAGINLSATLATALQNEISGSEAERWKRENSAAIQTLNRITEEHGLLSDDYRAF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References