Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 23712..24259 Replicon plasmid pK520-TEM
Accession NZ_CP118992
Organism Aeromonas allosaccharophila strain K520

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag PYU98_RS25650 Protein ID WP_134997959.1
Coordinates 23951..24259 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag PYU98_RS25645 Protein ID WP_134997958.1
Coordinates 23712..23951 (+) Length 80 a.a.

Genomic Context

PYU98_RS25635PYU98_RS25640PYU98_RS25645PYU98_RS25650PYU98_RS25655PYU98_RS25660PYU98_RS25665PYU98_RS25670PYU98_RS25675PYU98_RS25680PYU98_RS25685PYU98_RS25625PYU98_RS25630
Location: 22793..23242 (450 bp)
Type: Others
Protein ID: WP_275058455.1
Location: 23386..23655 (270 bp)
Type: Others
Protein ID: WP_270796694.1
Location: 23712..23951 (240 bp)
Type: Antitoxin
Protein ID: WP_134997958.1
Location: 23951..24259 (309 bp)
Type: Toxin
Protein ID: WP_134997959.1
Location: 24407..24901 (495 bp)
Type: Others
Protein ID: Protein_27
Location: 25043..25552 (510 bp)
Type: Others
Protein ID: Protein_28
Location: 25564..26157 (594 bp)
Type: Others
Protein ID: Protein_29
Location: 26195..26362 (168 bp)
Type: Others
Protein ID: WP_275058456.1
Location: 26492..27133 (642 bp)
Type: Others
Protein ID: WP_033147139.1
Location: 27172..27456 (285 bp)
Type: Others
Protein ID: WP_033147140.1
Location: 27679..28143 (465 bp)
Type: Others
Protein ID: Protein_33
Location: 20720..21157 (438 bp)
Type: Others
Protein ID: WP_244776905.1
Location: 21241..21888 (648 bp)
Type: Others
Protein ID: WP_270796700.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PYU98_RS25625 (PYU98_25625)20720..21157-438WP_244776905.1hypothetical protein-
PYU98_RS25630 (PYU98_25630)21241..21888-648WP_270796700.1DUF2914 domain-containing protein-
PYU98_RS25635 (PYU98_25635)22793..23242+450WP_275058455.1tetratricopeptide repeat protein-
PYU98_RS25640 (PYU98_25640)23386..23655+270WP_270796694.1hypothetical protein-
PYU98_RS25645 (PYU98_25645)23712..23951+240WP_134997958.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
PYU98_RS25650 (PYU98_25650)23951..24259+309WP_134997959.1CcdB family proteinToxin
PYU98_RS25655 (PYU98_25655)24407..24901+495Protein_27replication initiation protein-
PYU98_RS25660 (PYU98_25660)25043..25552+510Protein_28TetR/AcrR family transcriptional regulator-
PYU98_RS25665 (PYU98_25665)25564..26157+594Protein_29Tn3 family transposase-
PYU98_RS25670 (PYU98_25670)26195..26362+168WP_275058456.1hypothetical protein-
PYU98_RS25675 (PYU98_25675)26492..27133+642WP_033147139.1AAA family ATPase-
PYU98_RS25680 (PYU98_25680)27172..27456+285WP_033147140.1hypothetical protein-
PYU98_RS25685 (PYU98_25685)27679..28143+465Protein_33replication protein RepA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidblaTEM-1C-1..7388173881
-flankIS/Tn--25582..26157575


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11431.30 Da        Isoelectric Point: 4.6920

>T273702 WP_134997959.1 NZ_CP118992:23951-24259 [Aeromonas allosaccharophila]
MQFTIYRNKGNARAYPYLLDVQSDIIGELATRMVIPLFPLVAFTGRPAQRLNPVIIVEGDKYLVMTQDMAAVRLAQLGDE
VTGVQESRQLIKDAIDFLFDGV

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8659.76 Da        Isoelectric Point: 7.0125

>AT273702 WP_134997958.1 NZ_CP118992:23712-23951 [Aeromonas allosaccharophila]
MVAAAMRSKRTVSVTLEPSLLERARAAGINLSATLATALQNEISGSEAERWKRENSAAIQTLNRITEEHGLLSDDYRAF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References