273701

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 178517..179036 Replicon plasmid pK520-MPH
Accession NZ_CP118990
Organism Aeromonas allosaccharophila strain K520

Toxin (Protein)


Gene name relE Uniprot ID A0A2L0U0N7
Locus tag PYU98_RS25305 Protein ID WP_068979439.1
Coordinates 178517..178804 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2L0U081
Locus tag PYU98_RS25310 Protein ID WP_068979438.1
Coordinates 178794..179036 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYU98_RS25290 (PYU98_25290) 173689..174291 + 603 WP_010465829.1 recombinase family protein -
PYU98_RS25295 (PYU98_25295) 174275..177304 + 3030 WP_032432545.1 Tn3 family transposase -
PYU98_RS25300 (PYU98_25300) 177336..178334 - 999 WP_275058415.1 replication initiation protein -
PYU98_RS25305 (PYU98_25305) 178517..178804 - 288 WP_068979439.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PYU98_RS25310 (PYU98_25310) 178794..179036 - 243 WP_068979438.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PYU98_RS25315 (PYU98_25315) 179215..179844 + 630 WP_068979437.1 ParA family partition ATPase -
PYU98_RS25320 (PYU98_25320) 179841..180074 + 234 WP_068979436.1 hypothetical protein -
PYU98_RS25325 (PYU98_25325) 180142..181410 - 1269 WP_011191342.1 IS4-like element ISApu1 family transposase -
PYU98_RS25330 (PYU98_25330) 181728..182099 - 372 WP_004099020.1 hypothetical protein -
PYU98_RS25335 (PYU98_25335) 182256..183530 + 1275 WP_045892401.1 IS4-like element ISApu2 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 173566..191498 17932
- inside Non-Mobilizable plasmid msr(E) / mph(E) galU 1..208934 208934


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-62)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11370.15 Da        Isoelectric Point: 9.7908

>T273701 WP_068979439.1 NZ_CP118990:c178804-178517 [Aeromonas allosaccharophila]
MTFELEFDPRAWKEWKKLGDTVRQQFKKKLSEVIERPRIEANRLNGMSDCYKIKLRGAGYRLVYQVQDDRVVVFVVAVGR
REREEVYLDAMSRLD

Download         Length: 288 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8871.16 Da        Isoelectric Point: 4.7571

>AT273701 WP_068979438.1 NZ_CP118990:c179036-178794 [Aeromonas allosaccharophila]
MGTINLRIDDELKARSFAVLDKLGVTPSDIIRQTLEYVASQGRSPFRTTVVTEDEEALLAIVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0U0N7

Antitoxin

Source ID Structure
AlphaFold DB A0A2L0U081

References