Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 172804..173497 Replicon plasmid pK520-MPH
Accession NZ_CP118990
Organism Aeromonas allosaccharophila strain K520

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag PYU98_RS25285 Protein ID WP_000182276.1
Coordinates 173141..173497 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag PYU98_RS25280 Protein ID WP_001172026.1
Coordinates 172804..173139 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYU98_RS25240 (PYU98_25240) 168663..169274 - 612 WP_015060246.1 recombinase family protein -
PYU98_RS25245 (PYU98_25245) 169483..170013 - 531 WP_000172759.1 hypothetical protein -
PYU98_RS25250 (PYU98_25250) 170357..171049 - 693 WP_230679382.1 HD-GYP domain-containing protein -
PYU98_RS25255 (PYU98_25255) 171245..171349 - 105 Protein_177 hypothetical protein -
PYU98_RS25260 (PYU98_25260) 171310..171570 - 261 WP_239991406.1 DUF3391 domain-containing protein -
PYU98_RS25265 (PYU98_25265) 171727..172107 - 381 WP_001054412.1 hypothetical protein -
PYU98_RS25270 (PYU98_25270) 172104..172430 - 327 WP_000091614.1 hypothetical protein -
PYU98_RS25275 (PYU98_25275) 172454..172789 - 336 WP_000741275.1 hypothetical protein -
PYU98_RS25280 (PYU98_25280) 172804..173139 - 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
PYU98_RS25285 (PYU98_25285) 173141..173497 - 357 WP_000182276.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PYU98_RS25290 (PYU98_25290) 173689..174291 + 603 WP_010465829.1 recombinase family protein -
PYU98_RS25295 (PYU98_25295) 174275..177304 + 3030 WP_032432545.1 Tn3 family transposase -
PYU98_RS25300 (PYU98_25300) 177336..178334 - 999 WP_275058415.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid msr(E) / mph(E) galU 1..208934 208934
- inside IScluster/Tn - - 173566..191498 17932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12912.93 Da        Isoelectric Point: 8.9018

>T273700 WP_000182276.1 NZ_CP118990:c173497-173141 [Aeromonas allosaccharophila]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKELKGFGGAGVLKVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQEL

Download         Length: 357 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT273700 WP_001172026.1 NZ_CP118990:c173139-172804 [Aeromonas allosaccharophila]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References