Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4292..4860 Replicon plasmid pK520-KPC
Accession NZ_CP118989
Organism Aeromonas allosaccharophila strain K520

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PYU98_RS23210 Protein ID WP_101617266.1
Coordinates 4292..4585 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PYU98_RS23215 Protein ID WP_101617265.1
Coordinates 4573..4860 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYU98_RS23190 (PYU98_23190) 1..870 + 870 WP_148248203.1 replication protein RepA -
PYU98_RS23195 (PYU98_23195) 1873..2409 - 537 WP_107979027.1 tetratricopeptide repeat protein -
PYU98_RS23200 (PYU98_23200) 2468..2872 - 405 WP_010674034.1 IS200/IS605-like element ISAs26 family transposase -
PYU98_RS23205 (PYU98_23205) 2930..4156 + 1227 WP_021141234.1 RNA-guided endonuclease TnpB family protein -
PYU98_RS23210 (PYU98_23210) 4292..4585 - 294 WP_101617266.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PYU98_RS23215 (PYU98_23215) 4573..4860 - 288 WP_101617265.1 CopG family ribbon-helix-helix protein Antitoxin
PYU98_RS23220 (PYU98_23220) 4884..5402 + 519 WP_275058391.1 hypothetical protein -
PYU98_RS23225 (PYU98_23225) 5684..6442 - 759 WP_101617261.1 hypothetical protein -
PYU98_RS23230 (PYU98_23230) 7150..9747 - 2598 WP_101617259.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / aac(3)-IId / aph(6)-Id / aph(3'')-Ib / blaKPC-2 / aph(3')-VIb katB 1..243463 243463


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10980.79 Da        Isoelectric Point: 10.6871

>T273699 WP_101617266.1 NZ_CP118989:c4585-4292 [Aeromonas allosaccharophila]
MPPVIFAPAALRDLQRLREFLRPKSPQVAQRAATTIQLSLRQLAAQPSMGRPIEGLPEAFREWVIPFGDSGYLARYRIEP
DVIVVLAVRHQREVGYS

Download         Length: 294 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11047.15 Da        Isoelectric Point: 4.7091

>AT273699 WP_101617265.1 NZ_CP118989:c4860-4573 [Aeromonas allosaccharophila]
MPTQSKPVSIKLDADTQERIKRLATSRERSAHWLMREAISQYVEREELRETFHRDTLEAWQEFQETGQYATAQDVDQWLA
SWGTDAEGAPPACHQ

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References