273698

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2871462..2873026 Replicon chromosome
Accession NZ_CP118988
Organism Aeromonas allosaccharophila strain K520

Toxin (Protein)


Gene name hipA Uniprot ID A0A2S4TP05
Locus tag PYU98_RS13235 Protein ID WP_005329232.1
Coordinates 2871716..2873026 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PYU98_RS13230 Protein ID WP_005329233.1
Coordinates 2871462..2871716 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYU98_RS13205 (PYU98_13205) 2867037..2867615 - 579 WP_021140685.1 hypothetical protein -
PYU98_RS13210 (PYU98_13210) 2867947..2868399 - 453 WP_021140686.1 DUF2384 domain-containing protein -
PYU98_RS13215 (PYU98_13215) 2868579..2869961 + 1383 WP_197060245.1 Fic family protein -
PYU98_RS13220 (PYU98_13220) 2870040..2870291 + 252 WP_010674977.1 plasmid stabilization protein -
PYU98_RS13225 (PYU98_13225) 2870712..2870960 - 249 WP_010674978.1 hypothetical protein -
PYU98_RS13230 (PYU98_13230) 2871462..2871716 + 255 WP_005329233.1 helix-turn-helix domain-containing protein Antitoxin
PYU98_RS13235 (PYU98_13235) 2871716..2873026 + 1311 WP_005329232.1 type II toxin-antitoxin system HipA family toxin Toxin
PYU98_RS13245 (PYU98_13245) 2873793..2874503 + 711 WP_275056328.1 two-component system response regulator RstA -
PYU98_RS13250 (PYU98_13250) 2874525..2875850 + 1326 WP_275056329.1 two-component system sensor histidine kinase RstB -
PYU98_RS13255 (PYU98_13255) 2875905..2876087 + 183 WP_275056330.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49096.31 Da        Isoelectric Point: 7.1717

>T273698 WP_005329232.1 NZ_CP118988:2871716-2873026 [Aeromonas allosaccharophila]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQIMTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSKAQRLKR

Download         Length: 1311 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9271.66 Da        Isoelectric Point: 9.1571

>AT273698 WP_005329233.1 NZ_CP118988:2871462-2871716 [Aeromonas allosaccharophila]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4TP05

Antitoxin

Source ID Structure

References