Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 909203..909723 Replicon chromosome
Accession NZ_CP118982
Organism Staphylococcus equorum strain DSM 20674

Toxin (Protein)


Gene name TsdT Uniprot ID A0A192F7F2
Locus tag PYW44_RS04290 Protein ID WP_031266142.1
Coordinates 909511..909723 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID J9GWP4
Locus tag PYW44_RS04285 Protein ID WP_002507096.1
Coordinates 909203..909496 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW44_RS04260 904340..905131 + 792 WP_031266140.1 hydroxyethylthiazole kinase -
PYW44_RS04265 905131..905769 + 639 WP_021339941.1 thiamine phosphate synthase -
PYW44_RS04270 905857..906726 + 870 WP_002507093.1 membrane protein insertase YidC -
PYW44_RS04275 906797..907447 - 651 WP_021339942.1 HD domain-containing protein -
PYW44_RS04280 907575..909059 - 1485 WP_021339943.1 cardiolipin synthase -
PYW44_RS04285 909203..909496 + 294 WP_002507096.1 copper-sensing transcriptional repressor CsoR Antitoxin
PYW44_RS04290 909511..909723 + 213 WP_031266142.1 heavy metal-associated domain-containing protein Toxin
PYW44_RS04295 909938..910078 + 141 WP_002507098.1 Lmo0850 family protein -
PYW44_RS04300 910234..911436 - 1203 WP_002507099.1 rod shape-determining protein RodA -
PYW44_RS04305 911711..912781 + 1071 WP_002507100.1 D-alanine--D-alanine ligase -
PYW44_RS04310 912794..914149 + 1356 WP_021339945.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(18-67)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8116.13 Da        Isoelectric Point: 4.5086

>T273691 WP_031266142.1 NZ_CP118982:909511-909723 [Staphylococcus equorum]
VVTKVIYISGIENETQQKHIEQQLKQLHGVHQVNIEIESNNGKIFIDFETPASLNNLEKEVYDLGYEILY

Download         Length: 213 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11195.87 Da        Isoelectric Point: 6.4791

>AT273691 WP_002507096.1 NZ_CP118982:909203-909496 [Staphylococcus equorum]
MAEIQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNGVATKLLDHHMKSCIMEKVEQGQQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192F7F2

Antitoxin

Source ID Structure
AlphaFold DB J9GWP4

References