Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1036238..1037009 Replicon chromosome
Accession NZ_CP118979
Organism Staphylococcus haemolyticus strain DSM 20263

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag PYW40_RS05120 Protein ID WP_011275410.1
Coordinates 1036860..1037009 (+) Length 50 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q4L7F8
Locus tag PYW40_RS05115 Protein ID WP_011275409.1
Coordinates 1036238..1036837 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW40_RS05095 1032121..1033575 + 1455 WP_053019944.1 ABC transporter substrate-binding protein/permease -
PYW40_RS05100 1033568..1034290 + 723 WP_016931345.1 amino acid ABC transporter ATP-binding protein -
PYW40_RS05105 1034468..1035595 + 1128 WP_011275407.1 tRNA epoxyqueuosine(34) reductase QueG -
PYW40_RS05110 1035596..1036066 + 471 WP_016931343.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PYW40_RS05115 1036238..1036837 + 600 WP_011275409.1 glucosamine-6-phosphate isomerase Antitoxin
PYW40_RS05120 1036860..1037009 + 150 WP_011275410.1 SAS053 family protein Toxin
PYW40_RS05125 1037220..1037615 + 396 WP_057504773.1 hypothetical protein -
PYW40_RS05130 1037822..1039207 + 1386 WP_011275412.1 class II fumarate hydratase -
PYW40_RS05135 1039273..1040097 - 825 WP_011275413.1 RluA family pseudouridine synthase -
PYW40_RS05140 1040285..1041394 + 1110 WP_011275414.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5796.18 Da        Isoelectric Point: 3.9484

>T273687 WP_011275410.1 NZ_CP118979:1036860-1037009 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Download         Length: 150 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22272.12 Da        Isoelectric Point: 4.7588

>AT273687 WP_011275409.1 NZ_CP118979:1036238-1036837 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K9C2

References