Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 890410..890942 Replicon chromosome
Accession NZ_CP118979
Organism Staphylococcus haemolyticus strain DSM 20263

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag PYW40_RS04270 Protein ID WP_011275272.1
Coordinates 890577..890942 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag PYW40_RS04265 Protein ID WP_011275271.1
Coordinates 890410..890580 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW40_RS04240 886196..886675 + 480 WP_011275266.1 PH domain-containing protein -
PYW40_RS04245 886668..888191 + 1524 WP_016931363.1 PH domain-containing protein -
PYW40_RS04250 888184..888711 + 528 WP_016931364.1 PH domain-containing protein -
PYW40_RS04255 888721..889080 + 360 WP_037559766.1 holo-ACP synthase -
PYW40_RS04260 889176..890324 + 1149 WP_057504951.1 alanine racemase -
PYW40_RS04265 890410..890580 + 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYW40_RS04270 890577..890942 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYW40_RS04275 891250..892251 + 1002 WP_037559762.1 PP2C family protein-serine/threonine phosphatase -
PYW40_RS04280 892350..892676 + 327 WP_011275274.1 anti-sigma factor antagonist -
PYW40_RS04285 892705..893157 + 453 WP_046309853.1 anti-sigma B factor RsbW -
PYW40_RS04290 893132..893902 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T273686 WP_011275272.1 NZ_CP118979:890577-890942 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT273686 WP_011275271.1 NZ_CP118979:890410-890580 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References