Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 877485..877996 Replicon chromosome
Accession NZ_CP118979
Organism Staphylococcus haemolyticus strain DSM 20263

Toxin (Protein)


Gene name TsdT Uniprot ID Q4L7W7
Locus tag PYW40_RS04205 Protein ID WP_011275259.1
Coordinates 877790..877996 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag PYW40_RS04200 Protein ID WP_011275258.1
Coordinates 877485..877778 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW40_RS04180 872638..873513 + 876 WP_011275255.1 membrane protein insertase YidC -
PYW40_RS04185 873708..875024 + 1317 WP_058646542.1 ISL3-like element ISSha1 family transposase -
PYW40_RS04190 875073..875714 - 642 WP_016931420.1 HD domain-containing protein -
PYW40_RS04195 875814..877298 - 1485 WP_011275257.1 cardiolipin synthase -
PYW40_RS04200 877485..877778 + 294 WP_011275258.1 copper-sensing transcriptional repressor CsoR Antitoxin
PYW40_RS04205 877790..877996 + 207 WP_011275259.1 heavy-metal-associated domain-containing protein Toxin
PYW40_RS04210 878104..878241 + 138 WP_103261999.1 Lmo0850 family protein -
PYW40_RS04215 878538..880215 + 1678 Protein_830 IS1182 family transposase -
PYW40_RS04220 880190..881389 - 1200 WP_011275262.1 FtsW/RodA/SpoVE family cell cycle protein -
PYW40_RS04225 881807..882877 + 1071 WP_057504952.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 873708..880232 6524


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7857.79 Da        Isoelectric Point: 4.0742

>T273685 WP_011275259.1 NZ_CP118979:877790-877996 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11222.83 Da        Isoelectric Point: 6.6361

>AT273685 WP_011275258.1 NZ_CP118979:877485-877778 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1K7I8

Antitoxin

Source ID Structure

References