Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1048641..1049447 Replicon chromosome
Accession NZ_CP118976
Organism Staphylococcus succinus strain DSM 14617

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PYW31_RS05070 Protein ID WP_046836824.1
Coordinates 1048641..1049105 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag PYW31_RS05075 Protein ID WP_046836823.1
Coordinates 1049118..1049447 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW31_RS05015 1045118..1045675 + 558 WP_046838001.1 alpha/beta hydrolase -
PYW31_RS05060 1046921..1047985 - 1065 WP_046836826.1 site-specific integrase -
PYW31_RS05065 1048046..1048552 - 507 WP_046836825.1 hypothetical protein -
PYW31_RS05070 1048641..1049105 - 465 WP_046836824.1 ImmA/IrrE family metallo-endopeptidase Toxin
PYW31_RS05075 1049118..1049447 - 330 WP_046836823.1 helix-turn-helix transcriptional regulator Antitoxin
PYW31_RS05080 1049662..1049877 + 216 WP_240621337.1 helix-turn-helix transcriptional regulator -
PYW31_RS05085 1049919..1050800 + 882 WP_046836821.1 HNH endonuclease -
PYW31_RS05090 1050850..1051065 + 216 WP_046836820.1 DUF771 domain-containing protein -
PYW31_RS05095 1051079..1051252 + 174 WP_156168127.1 hypothetical protein -
PYW31_RS05100 1051316..1051537 + 222 WP_046836846.1 DUF2483 family protein -
PYW31_RS05105 1051530..1052144 + 615 WP_046836819.1 DUF1071 domain-containing protein -
PYW31_RS05110 1052147..1052560 + 414 WP_046836818.1 single-stranded DNA-binding protein -
PYW31_RS05115 1052573..1053241 + 669 WP_046836817.1 putative HNHc nuclease -
PYW31_RS05120 1053238..1053477 + 240 WP_053042472.1 helix-turn-helix transcriptional regulator -
PYW31_RS05125 1053479..1054261 + 783 WP_046836816.1 phage replisome organizer N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1045118..1085872 40754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(31-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17908.63 Da        Isoelectric Point: 6.6975

>T273684 WP_046836824.1 NZ_CP118976:c1049105-1048641 [Staphylococcus succinus]
VGNYEQLLIANDNIKIKETNVLPEELGGININKIILLNSKNKHVNKIEILAEELAHYKITYGDIRDQTNMLNRKFELKAR
RLGCELAVSLDDIIEAFHHGVHNLYGIAEFLEVSEKYVLKVIEHYKMKYGLSTYHNGYVIKFEPLQVFEHRNLD

Download         Length: 465 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12745.39 Da        Isoelectric Point: 5.2973

>AT273684 WP_046836823.1 NZ_CP118976:c1049447-1049118 [Staphylococcus succinus]
MRNNDEIISLITKLMDKQNLSTSELARRTNMAKSTVSRYLNKSREFPLNRADDFAKVLKVTPGYLLGLEEKKEENSFETI
AAHLDGELTEEQWKKVFEYARFIQENDDK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References