Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 863747..864276 Replicon chromosome
Accession NZ_CP118976
Organism Staphylococcus succinus strain DSM 14617

Toxin (Protein)


Gene name mazF Uniprot ID A0A1S2MGJ9
Locus tag PYW31_RS04030 Protein ID WP_046837772.1
Coordinates 863914..864276 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1S2MIN4
Locus tag PYW31_RS04025 Protein ID WP_046837773.1
Coordinates 863747..863917 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW31_RS04000 859517..859996 + 480 WP_046837778.1 PH domain-containing protein -
PYW31_RS04005 859989..861491 + 1503 WP_046837777.1 PH domain-containing protein -
PYW31_RS04010 861484..861990 + 507 WP_046837776.1 PH domain-containing protein -
PYW31_RS04015 862045..862395 + 351 WP_046837775.1 holo-ACP synthase -
PYW31_RS04020 862511..863659 + 1149 WP_046837774.1 alanine racemase -
PYW31_RS04025 863747..863917 + 171 WP_046837773.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYW31_RS04030 863914..864276 + 363 WP_046837772.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYW31_RS04035 864626..865627 + 1002 WP_046837771.1 PP2C family protein-serine/threonine phosphatase -
PYW31_RS04040 865707..866033 + 327 WP_046837770.1 anti-sigma factor antagonist -
PYW31_RS04045 866035..866517 + 483 WP_046837769.1 anti-sigma B factor RsbW -
PYW31_RS04050 866492..867262 + 771 Protein_798 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13476.56 Da        Isoelectric Point: 10.0960

>T273683 WP_046837772.1 NZ_CP118976:863914-864276 [Staphylococcus succinus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDDKMREVNNAIDISLGLHSVRTNKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6320.97 Da        Isoelectric Point: 4.0121

>AT273683 WP_046837773.1 NZ_CP118976:863747-863917 [Staphylococcus succinus]
MVSFTQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2MGJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2MIN4

References