Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 745480..746019 Replicon chromosome
Accession NZ_CP118974
Organism Mammaliicoccus vitulinus strain DSM 15615

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PTI0
Locus tag PYW35_RS03675 Protein ID WP_016910942.1
Coordinates 745648..746019 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PTG6
Locus tag PYW35_RS03670 Protein ID WP_016910943.1
Coordinates 745480..745647 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW35_RS03645 741367..741846 + 480 WP_016910948.1 PH domain-containing protein -
PYW35_RS03650 741836..743347 + 1512 WP_103322387.1 PH domain-containing protein -
PYW35_RS03655 743337..743819 + 483 WP_016910946.1 PH domain-containing protein -
PYW35_RS03660 743831..744199 + 369 WP_016910945.1 holo-ACP synthase -
PYW35_RS03665 744247..745395 + 1149 WP_103322388.1 alanine racemase -
PYW35_RS03670 745480..745647 + 168 WP_016910943.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYW35_RS03675 745648..746019 + 372 WP_016910942.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYW35_RS03680 746122..747126 + 1005 WP_016910941.1 PP2C family protein-serine/threonine phosphatase -
PYW35_RS03685 747200..747523 + 324 WP_016910940.1 anti-sigma factor antagonist -
PYW35_RS03690 747528..748004 + 477 WP_016910939.1 anti-sigma B factor RsbW -
PYW35_RS03695 747979..748749 + 771 WP_103322389.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13611.75 Da        Isoelectric Point: 9.9193

>T273681 WP_016910942.1 NZ_CP118974:745648-746019 [Mammaliicoccus vitulinus]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDTAIAISLNLTLQQKFDALGNT

Download         Length: 372 bp

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6120.58 Da        Isoelectric Point: 4.0121

>AT273681 WP_016910943.1 NZ_CP118974:745480-745647 [Mammaliicoccus vitulinus]
MTSLTQNRTQSIEQTLKEGYRSMADLNLSLASEAYYSECEACDSNESHLASQQGE

Download         Length: 168 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PTI0

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PTG6

References