Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 151257..151843 Replicon chromosome
Accession NZ_CP118974
Organism Mammaliicoccus vitulinus strain DSM 15615

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag PYW35_RS00760 Protein ID WP_103322579.1
Coordinates 151511..151843 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag PYW35_RS00755 Protein ID WP_103322578.1
Coordinates 151257..151517 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW35_RS00735 147193..148542 + 1350 WP_103322574.1 2-hydroxycarboxylate transporter family protein -
PYW35_RS00740 148574..149755 + 1182 WP_103322575.1 NADP-dependent malic enzyme -
PYW35_RS00745 149845..150564 - 720 WP_103322576.1 LysR family transcriptional regulator -
PYW35_RS00750 150662..151195 + 534 WP_103322577.1 DUF4865 family protein -
PYW35_RS00755 151257..151517 + 261 WP_103322578.1 AbrB family transcriptional regulator Antitoxin
PYW35_RS00760 151511..151843 + 333 WP_103322579.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYW35_RS00765 152094..152687 + 594 WP_103322580.1 hypothetical protein -
PYW35_RS00770 152854..154224 - 1371 WP_103322581.1 aminopeptidase P family N-terminal domain-containing protein -
PYW35_RS00775 154226..155008 - 783 WP_103322582.1 DeoR/GlpR family DNA-binding transcription regulator -
PYW35_RS00780 155174..156586 + 1413 WP_103322583.1 PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12516.52 Da        Isoelectric Point: 8.4783

>T273680 WP_103322579.1 NZ_CP118974:151511-151843 [Mammaliicoccus vitulinus]
MVKQYDIIKLNLNPVQGNEKGNYRPCLVVNITEFTKQSGFAWVIPITSRKQSRYPTDVIVETEKGLINGVVDCAHIRTVD
LYTRSHQKVDVLKANKIEEVKDILTGIMDL

Download         Length: 333 bp

>T273680 NZ_CP118974:151511-151843 [Mammaliicoccus vitulinus]
ATGGTAAAACAGTACGATATTATTAAATTAAATCTAAATCCTGTTCAAGGCAATGAAAAAGGAAATTATAGACCATGTTT
AGTCGTAAATATTACAGAGTTCACGAAACAATCTGGTTTCGCATGGGTTATACCTATTACATCACGTAAACAGTCACGCT
ATCCTACAGATGTTATAGTTGAAACAGAAAAAGGATTGATTAATGGTGTTGTAGATTGTGCTCACATTAGAACAGTTGAT
TTATATACACGTTCCCATCAAAAAGTTGATGTACTAAAAGCAAATAAGATAGAAGAAGTAAAAGATATTCTAACAGGTAT
TATGGATTTGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9950.21 Da        Isoelectric Point: 5.2300

>AT273680 WP_103322578.1 NZ_CP118974:151257-151517 [Mammaliicoccus vitulinus]
MSEPTNKAYAKVYKSGNGQVISIKKDMLEKAGFKIGDELVMNVKGNQIVLEKPNTFKDRWRKFIEDGGEYERGEYDWGES
VGREEW

Download         Length: 261 bp

>AT273680 NZ_CP118974:151257-151517 [Mammaliicoccus vitulinus]
ATGAGTGAACCAACCAATAAGGCATATGCTAAAGTATATAAAAGTGGTAATGGCCAGGTTATCAGTATTAAAAAAGATAT
GTTAGAAAAAGCAGGTTTTAAGATAGGGGATGAACTTGTTATGAATGTTAAAGGTAATCAAATTGTATTAGAAAAACCGA
ATACATTCAAAGACCGTTGGAGAAAGTTTATTGAAGATGGTGGAGAATATGAACGTGGTGAATACGATTGGGGAGAATCA
GTGGGGCGTGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References