Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tsbAT/- |
| Location | 947968..948774 | Replicon | chromosome |
| Accession | NZ_CP118973 | ||
| Organism | Staphylococcus warneri strain DSM 20316 | ||
Toxin (Protein)
| Gene name | tsbT | Uniprot ID | A0A364UNB4 |
| Locus tag | PYW39_RS04785 | Protein ID | WP_002466824.1 |
| Coordinates | 948595..948774 (+) | Length | 60 a.a. |
Antitoxin (Protein)
| Gene name | tsbA | Uniprot ID | A0A364UN40 |
| Locus tag | PYW39_RS04780 | Protein ID | WP_015364870.1 |
| Coordinates | 947968..948567 (+) | Length | 200 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PYW39_RS04760 | 943769..945229 | + | 1461 | WP_002466813.1 | ABC transporter substrate-binding protein/permease | - |
| PYW39_RS04765 | 945222..945944 | + | 723 | WP_002466809.1 | amino acid ABC transporter ATP-binding protein | - |
| PYW39_RS04770 | 946187..947317 | + | 1131 | WP_002466804.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
| PYW39_RS04775 | 947318..947788 | + | 471 | WP_002466802.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
| PYW39_RS04780 | 947968..948567 | + | 600 | WP_015364870.1 | glucosamine-6-phosphate isomerase | Antitoxin |
| PYW39_RS04785 | 948595..948774 | + | 180 | WP_002466824.1 | SAS053 family protein | Toxin |
| PYW39_RS04790 | 948917..949309 | + | 393 | WP_015364871.1 | hypothetical protein | - |
| PYW39_RS04795 | 949464..950849 | + | 1386 | WP_002466811.1 | class II fumarate hydratase | - |
| PYW39_RS04800 | 950910..951740 | - | 831 | WP_049416173.1 | RluA family pseudouridine synthase | - |
| PYW39_RS04805 | 951918..953030 | + | 1113 | WP_002466816.1 | GAF domain-containing sensor histidine kinase | - |
| PYW39_RS04810 | 953051..953674 | + | 624 | WP_002466822.1 | response regulator transcription factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6901.22 Da Isoelectric Point: 3.8441
>T273676 WP_002466824.1 NZ_CP118973:948595-948774 [Staphylococcus warneri]
MTQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEEKLNQSHDSDVRSDLDQD
MTQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEEKLNQSHDSDVRSDLDQD
Download Length: 180 bp
Antitoxin
Download Length: 200 a.a. Molecular weight: 22602.48 Da Isoelectric Point: 4.8492
>AT273676 WP_015364870.1 NZ_CP118973:947968-948567 [Staphylococcus warneri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDENQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDENGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDENQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDENGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
Download Length: 600 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A364UNB4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A364UN40 |