Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 811199..811728 Replicon chromosome
Accession NZ_CP118973
Organism Staphylococcus warneri strain DSM 20316

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PXE7
Locus tag PYW39_RS03985 Protein ID WP_002451625.1
Coordinates 811366..811728 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag PYW39_RS03980 Protein ID WP_002451626.1
Coordinates 811199..811369 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW39_RS03955 807024..807497 + 474 WP_002466763.1 PH domain-containing protein -
PYW39_RS03960 807490..809016 + 1527 WP_164553444.1 PH domain-containing protein -
PYW39_RS03965 809003..809506 + 504 WP_015364833.1 PH domain-containing protein -
PYW39_RS03970 809533..809907 + 375 WP_002466788.1 holo-ACP synthase -
PYW39_RS03975 809959..811107 + 1149 WP_015364834.1 alanine racemase -
PYW39_RS03980 811199..811369 + 171 WP_002451626.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYW39_RS03985 811366..811728 + 363 WP_002451625.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYW39_RS03990 812051..813052 + 1002 WP_002466762.1 PP2C family protein-serine/threonine phosphatase -
PYW39_RS03995 813146..813472 + 327 WP_002466754.1 anti-sigma factor antagonist -
PYW39_RS04000 813474..813953 + 480 WP_049414624.1 anti-sigma B factor RsbW -
PYW39_RS04005 813928..814698 + 771 WP_002451621.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13562.68 Da        Isoelectric Point: 9.9783

>T273675 WP_002451625.1 NZ_CP118973:811366-811728 [Staphylococcus warneri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHSKT

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT273675 WP_002451626.1 NZ_CP118973:811199-811369 [Staphylococcus warneri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PXE7

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References