273656

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2770897..2771468 Replicon chromosome
Accession NZ_CP118962
Organism Enterococcus faecalis strain DSM 20478

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag PYW42_RS13660 Protein ID WP_002360937.1
Coordinates 2770897..2771238 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag PYW42_RS13665 Protein ID WP_002367500.1
Coordinates 2771238..2771468 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW42_RS13655 (2766912) 2766912..2770526 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
PYW42_RS13660 (2770897) 2770897..2771238 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYW42_RS13665 (2771238) 2771238..2771468 - 231 WP_002367500.1 hypothetical protein Antitoxin
PYW42_RS13670 (2771523) 2771523..2771702 - 180 WP_111997057.1 hypothetical protein -
PYW42_RS13675 (2771882) 2771882..2772097 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PYW42_RS13680 (2772236) 2772236..2773228 + 993 WP_002389493.1 biotin--[acetyl-CoA-carboxylase] ligase -
PYW42_RS13685 (2773492) 2773492..2774130 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
PYW42_RS13690 (2774816) 2774816..2776432 + 1617 WP_002389442.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T273656 WP_002360937.1 NZ_CP118962:c2771238-2770897 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT273656 WP_002367500.1 NZ_CP118962:c2771468-2771238 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References