273645

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/Peptidase_M78-HTH_19
Location 2475789..2476483 Replicon chromosome
Accession NZ_CP118962
Organism Enterococcus faecalis strain DSM 20478

Toxin (Protein)


Gene name IrrE Uniprot ID A0A828QV40
Locus tag PYW42_RS12345 Protein ID WP_002406159.1
Coordinates 2476139..2476483 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID A0A828QTI6
Locus tag PYW42_RS12340 Protein ID WP_002406160.1
Coordinates 2475789..2476121 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW42_RS12305 (2471559) 2471559..2472335 - 777 WP_010816191.1 DnaD domain protein -
PYW42_RS12310 (2472351) 2472351..2473166 - 816 WP_010816192.1 PD-(D/E)XK nuclease-like domain-containing protein -
PYW42_RS12315 (2473129) 2473129..2474094 - 966 WP_010717378.1 RecT family recombinase -
PYW42_RS12320 (2474195) 2474195..2474419 - 225 WP_002367281.1 hypothetical protein -
PYW42_RS12325 (2474528) 2474528..2474944 - 417 WP_002370016.1 hypothetical protein -
PYW42_RS12330 (2475138) 2475138..2475281 - 144 WP_002393055.1 hypothetical protein -
PYW42_RS12335 (2475292) 2475292..2475468 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
PYW42_RS12340 (2475789) 2475789..2476121 + 333 WP_002406160.1 helix-turn-helix transcriptional regulator Antitoxin
PYW42_RS12345 (2476139) 2476139..2476483 + 345 WP_002406159.1 ImmA/IrrE family metallo-endopeptidase Toxin
PYW42_RS12350 (2476571) 2476571..2477002 + 432 WP_010784248.1 hypothetical protein -
PYW42_RS12355 (2477112) 2477112..2478479 + 1368 WP_002406157.1 recombinase family protein -
PYW42_RS12360 (2478501) 2478501..2479076 - 576 WP_002393061.1 DNA repair protein RadC -
PYW42_RS12365 (2479108) 2479108..2479767 - 660 WP_002398690.1 HAD family hydrolase -
PYW42_RS12370 (2479751) 2479751..2481073 - 1323 WP_002410879.1 folylpolyglutamate synthase/dihydrofolate synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2434292..2478479 44187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(24-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13556.36 Da        Isoelectric Point: 4.9882

>T273645 WP_002406159.1 NZ_CP118962:2476139-2476483 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLHKKACFESEHGVIFVNQNLSTEEQEEAIYHEFKHVKDHADLMALYNIPIFRSKMEAEAEH
YMFECLIEKNDGQFNYSNVITHYNLKMGQETYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12575.25 Da        Isoelectric Point: 5.2423

>AT273645 WP_002406160.1 NZ_CP118962:2475789-2476121 [Enterococcus faecalis]
MTAFDRIKKITDRRGISINELENRVGISQNVLYGWKKKTPGGENLTKVAKYLNISTDYILGIVDNPEPFVEKKTDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828QV40

Antitoxin

Source ID Structure
AlphaFold DB A0A828QTI6

References