273642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 412660..413242 Replicon chromosome
Accession NZ_CP118962
Organism Enterococcus faecalis strain DSM 20478

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag PYW42_RS02075 Protein ID WP_002355414.1
Coordinates 412934..413242 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag PYW42_RS02070 Protein ID WP_002326825.1
Coordinates 412660..412932 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW42_RS02040 (407941) 407941..408669 - 729 WP_002355404.1 GntR family transcriptional regulator -
PYW42_RS02045 (408846) 408846..409772 + 927 WP_002355406.1 hypothetical protein -
PYW42_RS02050 (409789) 409789..411072 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
PYW42_RS02055 (411264) 411264..411386 + 123 Protein_381 topoisomerase -
PYW42_RS02060 (411461) 411461..412357 + 897 WP_002363034.1 ParA family protein -
PYW42_RS02065 (412434) 412434..412643 + 210 WP_002363035.1 peptide-binding protein -
PYW42_RS02070 (412660) 412660..412932 + 273 WP_002326825.1 antitoxin Antitoxin
PYW42_RS02075 (412934) 412934..413242 + 309 WP_002355414.1 zeta toxin family protein Toxin
PYW42_RS02080 (413322) 413322..413729 - 408 WP_224571294.1 tyrosine-type recombinase/integrase -
PYW42_RS02085 (413796) 413796..414296 - 501 WP_002363039.1 HAD family hydrolase -
PYW42_RS02090 (414301) 414301..415068 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
PYW42_RS02095 (415555) 415555..415980 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
PYW42_RS02100 (415997) 415997..416512 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
PYW42_RS02105 (416523) 416523..417455 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T273642 WP_002355414.1 NZ_CP118962:412934-413242 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT273642 WP_002326825.1 NZ_CP118962:412660-412932 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References