Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2312655..2313633 Replicon chromosome
Accession NZ_CP118958
Organism Bacillus mycoides strain DSM 2048

Toxin (Protein)


Gene name spoIISA Uniprot ID J8I6P2
Locus tag PYW38_RS12035 Protein ID WP_002017051.1
Coordinates 2312655..2313395 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag PYW38_RS12040 Protein ID WP_000588712.1
Coordinates 2313508..2313633 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW38_RS12005 2307757..2308518 + 762 WP_002127420.1 ABC transporter ATP-binding protein -
PYW38_RS12010 2308624..2309334 + 711 WP_002127421.1 class I SAM-dependent methyltransferase -
PYW38_RS12015 2309453..2309866 + 414 WP_002012925.1 VOC family protein -
PYW38_RS12020 2310043..2310675 - 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
PYW38_RS12025 2310949..2311425 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
PYW38_RS12030 2311579..2312316 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
PYW38_RS12035 2312655..2313395 + 741 WP_002017051.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PYW38_RS12040 2313508..2313633 + 126 WP_000588712.1 hypothetical protein Antitoxin
PYW38_RS12045 2313709..2313885 + 177 WP_003189253.1 stage II sporulation protein SB -
PYW38_RS12050 2313906..2314295 - 390 WP_033733970.1 YxeA family protein -
PYW38_RS12055 2314547..2316016 + 1470 WP_003189257.1 aminoacyl-histidine dipeptidase -
PYW38_RS12060 2316376..2316525 + 150 WP_002069316.1 hypothetical protein -
PYW38_RS12065 2317239..2317898 + 660 WP_003189261.1 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28512.20 Da        Isoelectric Point: 8.3034

>T273640 WP_002017051.1 NZ_CP118958:2312655-2313395 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT273640 WP_000588712.1 NZ_CP118958:2313508-2313633 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J8I6P2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References