Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 245270..245912 Replicon chromosome
Accession NZ_CP118958
Organism Bacillus mycoides strain DSM 2048

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag PYW38_RS01380 Protein ID WP_000635965.1
Coordinates 245562..245912 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag PYW38_RS01375 Protein ID WP_000004570.1
Coordinates 245270..245557 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW38_RS01350 240435..241397 + 963 WP_002009966.1 UV DNA damage repair endonuclease UvsE -
PYW38_RS01355 241564..242112 - 549 WP_003186998.1 rhomboid family intramembrane serine protease -
PYW38_RS01360 242205..242564 + 360 WP_002009969.1 holo-ACP synthase -
PYW38_RS01365 242721..243671 + 951 WP_033734626.1 outer membrane lipoprotein carrier protein LolA -
PYW38_RS01370 243789..244958 + 1170 WP_002124821.1 alanine racemase -
PYW38_RS01375 245270..245557 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
PYW38_RS01380 245562..245912 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
PYW38_RS01385 245981..248149 + 2169 WP_002124824.1 Tex family protein -
PYW38_RS01390 248207..248323 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
PYW38_RS01395 248534..248989 + 456 WP_016095131.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T273639 WP_000635965.1 NZ_CP118958:245562-245912 [Bacillus mycoides]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT273639 WP_000004570.1 NZ_CP118958:245270-245557 [Bacillus mycoides]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References