Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 756722..757246 Replicon chromosome
Accession NZ_CP118953
Organism Staphylococcus chromogenes strain DSM 20454

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PYW36_RS03565 Protein ID WP_103159488.1
Coordinates 756893..757246 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A3A0K2V6
Locus tag PYW36_RS03560 Protein ID WP_037577177.1
Coordinates 756722..756892 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYW36_RS03535 752570..753043 + 474 WP_051605022.1 PH domain-containing protein -
PYW36_RS03540 753036..754514 + 1479 WP_037577183.1 PH domain-containing protein -
PYW36_RS03545 754511..755026 + 516 WP_051605021.1 PH domain-containing protein -
PYW36_RS03550 755023..755373 + 351 WP_037577181.1 holo-ACP synthase -
PYW36_RS03555 755489..756637 + 1149 WP_103159487.1 alanine racemase -
PYW36_RS03560 756722..756892 + 171 WP_037577177.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PYW36_RS03565 756893..757246 + 354 WP_103159488.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYW36_RS03570 757310..758314 + 1005 WP_037577174.1 PP2C family protein-serine/threonine phosphatase -
PYW36_RS03575 758395..758721 + 327 WP_037577172.1 anti-sigma factor antagonist -
PYW36_RS03580 758724..759203 + 480 WP_037577169.1 anti-sigma B factor RsbW -
PYW36_RS03585 759178..759948 + 771 WP_037577167.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13064.34 Da        Isoelectric Point: 10.5127

>T273634 WP_103159488.1 NZ_CP118953:756893-757246 [Staphylococcus chromogenes]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIDKKKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6328.01 Da        Isoelectric Point: 4.2313

>AT273634 WP_037577177.1 NZ_CP118953:756722-756892 [Staphylococcus chromogenes]
MSAFNQTRVKSLEQSLKEGYVQMADLNLSLATEAYFVECEACDCNESHLLSNHKDD

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3A0K2V6

References