Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 57174..58527 | Replicon | plasmid pK533-strA |
| Accession | NZ_CP118944 | ||
| Organism | Aeromonas hydrophila strain K533 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | - |
| Locus tag | PY771_RS25335 | Protein ID | WP_275116018.1 |
| Coordinates | 57174..58139 (-) | Length | 322 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | - |
| Locus tag | PY771_RS25340 | Protein ID | WP_085044707.1 |
| Coordinates | 58129..58527 (-) | Length | 133 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PY771_RS25310 (PY771_25310) | 53156..54979 | - | 1824 | WP_275116016.1 | AAA family ATPase | - |
| PY771_RS25315 (PY771_25315) | 54984..55538 | - | 555 | WP_275116017.1 | recombinase family protein | - |
| PY771_RS25320 (PY771_25320) | 55704..55910 | + | 207 | Protein_51 | DUF4158 domain-containing protein | - |
| PY771_RS25325 (PY771_25325) | 56247..56738 | - | 492 | WP_242431374.1 | hypothetical protein | - |
| PY771_RS25330 (PY771_25330) | 56763..57128 | - | 366 | WP_042468255.1 | hypothetical protein | - |
| PY771_RS25335 (PY771_25335) | 57174..58139 | - | 966 | WP_275116018.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| PY771_RS25340 (PY771_25340) | 58129..58527 | - | 399 | WP_085044707.1 | DUF6088 family protein | Antitoxin |
| PY771_RS25345 (PY771_25345) | 59464..59910 | + | 447 | WP_075116317.1 | DNA repair protein RadC | - |
| PY771_RS25350 (PY771_25350) | 59950..60312 | + | 363 | WP_005321010.1 | hypothetical protein | - |
| PY771_RS25355 (PY771_25355) | 60488..61663 | - | 1176 | WP_275116019.1 | ISAs1-like element ISAs12 family transposase | - |
| PY771_RS25360 (PY771_25360) | 61866..62114 | - | 249 | WP_275116020.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aph(3'')-Ib / aph(6)-Id | - | 1..100830 | 100830 | |
| - | inside | IScluster/Tn | - | - | 54984..61663 | 6679 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 322 a.a. Molecular weight: 36320.42 Da Isoelectric Point: 5.2657
>T273632 WP_275116018.1 NZ_CP118944:c58139-57174 [Aeromonas hydrophila]
MQPKDASIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHSCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVEKAEVTCRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQGPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHEL
I
MQPKDASIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHSCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVEKAEVTCRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQGPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHEL
I
Download Length: 966 bp
Antitoxin
Download Length: 133 a.a. Molecular weight: 14775.39 Da Isoelectric Point: 11.0142
>AT273632 WP_085044707.1 NZ_CP118944:c58527-58129 [Aeromonas hydrophila]
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQIPAFMEVKPKKRFSRKLKIGSRVFNAA
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQIPAFMEVKPKKRFSRKLKIGSRVFNAA
Download Length: 399 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|