Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 856737..858451 Replicon chromosome
Accession NZ_CP118942
Organism Aeromonas hydrophila strain K533

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag PY771_RS04255 Protein ID WP_024945033.1
Coordinates 856737..857390 (+) Length 218 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag PY771_RS04260 Protein ID WP_275115740.1
Coordinates 857438..858451 (+) Length 338 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY771_RS04240 (PY771_04240) 852091..854541 + 2451 WP_024945036.1 type I restriction-modification system subunit M -
PY771_RS04245 (PY771_04245) 854538..855029 + 492 WP_051505340.1 DUF1016 N-terminal domain-containing protein -
PY771_RS04250 (PY771_04250) 855026..856459 + 1434 WP_024945034.1 restriction endonuclease subunit S -
PY771_RS04255 (PY771_04255) 856737..857390 + 654 WP_024945033.1 DUF4433 domain-containing protein Toxin
PY771_RS04260 (PY771_04260) 857438..858451 + 1014 WP_275115740.1 macro domain-containing protein Antitoxin
PY771_RS04265 (PY771_04265) 858526..861657 + 3132 WP_264098721.1 HsdR family type I site-specific deoxyribonuclease -
PY771_RS04270 (PY771_04270) 861657..862370 + 714 WP_005331303.1 SprT family zinc-dependent metalloprotease -
PY771_RS04275 (PY771_04275) 862389..863327 - 939 WP_021138001.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-216)

Antitoxin

Macro domain

(1-114)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 25288.93 Da        Isoelectric Point: 6.9658

>T273628 WP_024945033.1 NZ_CP118942:856737-857390 [Aeromonas hydrophila]
MAYDYSQSLNPQKALIFRIVHRDNLEWILTHGLWAGNGLQQSPQWVHIGLPELIAKRARHPVPLAPYGVLNDYVPFYFTP
FSPMLSNIHSGRGVPQRENDEILILVSSLHRLAELGLPFVFTDSHAYYQWANFYVDLGDLGRIDWPLLQRRDFKRDAEDL
SKLERYQAEALIHQHCPIEALLGVVCYNEEIKNRVEQCMNRVGVARPVYVRDGWYFR

Download         Length: 654 bp

Antitoxin


Download         Length: 338 a.a.        Molecular weight: 37657.47 Da        Isoelectric Point: 7.2911

>AT273628 WP_275115740.1 NZ_CP118942:857438-858451 [Aeromonas hydrophila]
VNTVNTVGVMGKGIALMFKERFPANMRAYAEACKQGDVVTGKMFITQTGELLGPRWIVNFPTKQHWRNPAQMAWIQDGLQ
DLRAWLQAQQVSSIAIPPLGAGNGGLPWPAVKQAIETALGDLDIDILLYEPSSQYQNVAKRGGVAELTPARALIAELVRR
YWFLGMECSLLEIQKLAWFLARVIGRNPLGDPLQLQFKAHRYGPYANNLTHLLNAMDGSYLQSDKRIPDSKPFDVIWFNE
AKKQELAVYLQTEAKAFLPILEQTTALIDGFESPYGMELLATVDWLIAEEGCAPTVSALREGLHRWPAGTPWGERKARLF
DDRSLQIALTRLQQGLV

Download         Length: 1014 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References