Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 130970..131538 Replicon plasmid pK524-KPC
Accession NZ_CP118940
Organism Aeromonas caviae strain K524

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PY772_RS24415 Protein ID WP_101617266.1
Coordinates 130970..131263 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PY772_RS24420 Protein ID WP_101617265.1
Coordinates 131251..131538 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY772_RS24390 (PY772_24390) 127630..127902 - 273 WP_139743096.1 hypothetical protein -
PY772_RS24395 (PY772_24395) 127923..128066 - 144 WP_275059513.1 hypothetical protein -
PY772_RS24400 (PY772_24400) 128233..129843 - 1611 WP_052814785.1 IS66 family transposase -
PY772_RS24405 (PY772_24405) 129893..130258 - 366 WP_042012890.1 IS66 family insertion sequence element accessory protein TnpB -
PY772_RS24410 (PY772_24410) 130258..130566 - 309 WP_042012893.1 hypothetical protein -
PY772_RS24415 (PY772_24415) 130970..131263 - 294 WP_101617266.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PY772_RS24420 (PY772_24420) 131251..131538 - 288 WP_101617265.1 CopG family ribbon-helix-helix protein Antitoxin
PY772_RS24425 (PY772_24425) 131794..134811 - 3018 WP_021740570.1 Tn3-like element IS3000 family transposase -
PY772_RS24430 (PY772_24430) 134955..135812 + 858 Protein_131 IS481-like element ISKpn27 family transposase -
PY772_RS24435 (PY772_24435) 135887..136537 + 651 WP_045286946.1 class A beta-lactamase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / mph(A) / sul1 / blaKPC-2 / blaPER-3 / qacE / catB3 / ant(3'')-Ii-aac(6')-IId / aph(6)-Id / aph(3'')-Ib - 1..220105 220105
- inside IScluster/Tn mph(A) / sul1 / blaKPC-2 / blaPER-3 / qacE / catB3 / ant(3'')-Ii-aac(6')-IId / aph(6)-Id / aph(3'')-Ib - 111070..165395 54325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10980.79 Da        Isoelectric Point: 10.6871

>T273623 WP_101617266.1 NZ_CP118940:c131263-130970 [Aeromonas caviae]
MPPVIFAPAALRDLQRLREFLRPKSPQVAQRAATTIQLSLRQLAAQPSMGRPIEGLPEAFREWVIPFGDSGYLARYRIEP
DVIVVLAVRHQREVGYS

Download         Length: 294 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11047.15 Da        Isoelectric Point: 4.7091

>AT273623 WP_101617265.1 NZ_CP118940:c131538-131251 [Aeromonas caviae]
MPTQSKPVSIKLDADTQERIKRLATSRERSAHWLMREAISQYVEREELRETFHRDTLEAWQEFQETGQYATAQDVDQWLA
SWGTDAEGAPPACHQ

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References