Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2787080..2788644 Replicon chromosome
Accession NZ_CP118939
Organism Aeromonas caviae strain K524

Toxin (Protein)


Gene name hipA Uniprot ID A0A2L0TXX7
Locus tag PY772_RS13060 Protein ID WP_059169586.1
Coordinates 2787334..2788644 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PY772_RS13055 Protein ID WP_005329233.1
Coordinates 2787080..2787334 (+) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY772_RS13030 (PY772_13030) 2782655..2783233 - 579 WP_021140685.1 hypothetical protein -
PY772_RS13035 (PY772_13035) 2783565..2784017 - 453 WP_021140686.1 DUF2384 domain-containing protein -
PY772_RS13040 (PY772_13040) 2784272..2785579 + 1308 WP_270825577.1 Fic family protein -
PY772_RS13045 (PY772_13045) 2785658..2785909 + 252 WP_010674977.1 plasmid stabilization protein -
PY772_RS13050 (PY772_13050) 2786330..2786578 - 249 WP_160839436.1 hypothetical protein -
PY772_RS13055 (PY772_13055) 2787080..2787334 + 255 WP_005329233.1 helix-turn-helix domain-containing protein Antitoxin
PY772_RS13060 (PY772_13060) 2787334..2788644 + 1311 WP_059169586.1 type II toxin-antitoxin system HipA family toxin Toxin
PY772_RS13070 (PY772_13070) 2789501..2790532 + 1032 WP_114523370.1 IS630-like element ISAhy2 family transposase -
PY772_RS13080 (PY772_13080) 2792474..2793064 + 591 WP_223917505.1 restriction endonuclease subunit S -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-104)

Antitoxin

(13-65)


Sequences


Toxin        


Download         Length: 437 a.a.        Molecular weight: 49136.32 Da        Isoelectric Point: 7.1717

>T273620 WP_059169586.1 NZ_CP118939:2787334-2788644 [Aeromonas caviae]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQILTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKTIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSRAQRLKR

Download         Length: 1311 bp


Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9271.66 Da        Isoelectric Point: 9.1571

>AT273620 WP_005329233.1 NZ_CP118939:2787080-2787334 [Aeromonas caviae]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Download         Length: 255 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2L0TXX7


Antitoxin

Source ID Structure

References