Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 132171..133735 Replicon chromosome
Accession NZ_CP118939
Organism Aeromonas caviae strain K524

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PY772_RS00600 Protein ID WP_275058981.1
Coordinates 132171..133481 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PY772_RS00605 Protein ID WP_042656123.1
Coordinates 133481..133735 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY772_RS00580 (PY772_00580) 127239..128015 - 777 WP_268452550.1 glycosyltransferase family 2 protein -
PY772_RS00585 (PY772_00585) 128355..129452 + 1098 WP_143236896.1 lipopolysaccharide heptosyltransferase II -
PY772_RS00590 (PY772_00590) 129454..130722 + 1269 WP_143236897.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
PY772_RS00595 (PY772_00595) 130834..131712 + 879 WP_049636086.1 DMT family transporter -
PY772_RS00600 (PY772_00600) 132171..133481 - 1311 WP_275058981.1 type II toxin-antitoxin system HipA family toxin Toxin
PY772_RS00605 (PY772_00605) 133481..133735 - 255 WP_042656123.1 helix-turn-helix domain-containing protein Antitoxin
PY772_RS00610 (PY772_00610) 133905..134333 - 429 WP_257712445.1 DUF86 domain-containing protein -
PY772_RS00615 (PY772_00615) 134336..134770 - 435 WP_202043296.1 nucleotidyltransferase domain-containing protein -
PY772_RS00620 (PY772_00620) 135932..136555 + 624 WP_275058982.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49210.29 Da        Isoelectric Point: 7.0583

>T273619 WP_275058981.1 NZ_CP118939:c133481-132171 [Aeromonas caviae]
MANLAAYMNGYRVGTFTKTTSGAHQFQYHVSWLAQPGSRPISLSMPLRHQPYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHEVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYICTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGRGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAVGFEKVQMEMILNEMASSL
DEVISAVRQQLPDTFPAQIADSILDGLSTRAQRLTR

Download         Length: 1311 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9335.70 Da        Isoelectric Point: 7.9834

>AT273619 WP_042656123.1 NZ_CP118939:c133735-133481 [Aeromonas caviae]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPISGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References