Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4649972..4650488 Replicon chromosome
Accession NZ_CP118936
Organism Klebsiella pneumoniae subsp. pneumoniae strain RX.G5M15

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag PX704_RS22550 Protein ID WP_009486548.1
Coordinates 4649972..4650256 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PX704_RS22555 Protein ID WP_002886901.1
Coordinates 4650246..4650488 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX704_RS22525 (4645368) 4645368..4645631 - 264 WP_228938441.1 PTS sugar transporter subunit IIB -
PX704_RS22530 (4645761) 4645761..4645934 + 174 WP_032408826.1 hypothetical protein -
PX704_RS22535 (4645937) 4645937..4646680 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PX704_RS22540 (4647037) 4647037..4649175 + 2139 WP_040164650.1 anaerobic ribonucleoside-triphosphate reductase -
PX704_RS22545 (4649504) 4649504..4649968 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PX704_RS22550 (4649972) 4649972..4650256 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PX704_RS22555 (4650246) 4650246..4650488 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PX704_RS22560 (4650566) 4650566..4652476 - 1911 WP_009486549.1 PRD domain-containing protein -
PX704_RS22565 (4652499) 4652499..4653650 - 1152 WP_275107564.1 lactonase family protein -
PX704_RS22570 (4653717) 4653717..4654457 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T273616 WP_009486548.1 NZ_CP118936:c4650256-4649972 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT273616 WP_002886901.1 NZ_CP118936:c4650488-4650246 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References