Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4543734..4544544 Replicon chromosome
Accession NZ_CP118936
Organism Klebsiella pneumoniae subsp. pneumoniae strain RX.G5M15

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag PX704_RS22110 Protein ID WP_048299784.1
Coordinates 4543734..4544267 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag PX704_RS22115 Protein ID WP_002887278.1
Coordinates 4544278..4544544 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX704_RS22105 (4542565) 4542565..4543686 + 1122 WP_004214138.1 cupin domain-containing protein -
PX704_RS22110 (4543734) 4543734..4544267 - 534 WP_048299784.1 type II toxin-antitoxin system toxin KacT Toxin
PX704_RS22115 (4544278) 4544278..4544544 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
PX704_RS22120 (4544647) 4544647..4546080 - 1434 WP_040210879.1 Cu(+)/Ag(+) sensor histidine kinase -
PX704_RS22125 (4546070) 4546070..4546753 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
PX704_RS22130 (4546925) 4546925..4548310 + 1386 WP_040089708.1 efflux transporter outer membrane subunit -
PX704_RS22135 (4548328) 4548328..4548672 + 345 WP_023287080.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19826.65 Da        Isoelectric Point: 5.2614

>T273615 WP_048299784.1 NZ_CP118936:c4544267-4543734 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGYDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT273615 WP_002887278.1 NZ_CP118936:c4544544-4544278 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References