Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1751932..1752522 Replicon chromosome
Accession NZ_CP118936
Organism Klebsiella pneumoniae subsp. pneumoniae strain RX.G5M15

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag PX704_RS08405 Protein ID WP_023341911.1
Coordinates 1752190..1752522 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3S7DDD0
Locus tag PX704_RS08400 Protein ID WP_000288812.1
Coordinates 1751932..1752189 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX704_RS08375 (1747842) 1747842..1747916 + 75 Protein_1638 type II toxin-antitoxin system PemK/MazF family toxin -
PX704_RS08380 (1748267) 1748267..1750015 + 1749 WP_275107605.1 hypothetical protein -
PX704_RS08385 (1750094) 1750094..1750651 + 558 WP_087638062.1 hypothetical protein -
PX704_RS08390 (1750934) 1750934..1751394 + 461 Protein_1641 hypothetical protein -
PX704_RS08395 (1751391) 1751391..1751597 + 207 WP_022615589.1 helix-turn-helix transcriptional regulator -
PX704_RS08400 (1751932) 1751932..1752189 + 258 WP_000288812.1 antitoxin Antitoxin
PX704_RS08405 (1752190) 1752190..1752522 + 333 WP_023341911.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PX704_RS08415 (1752844) 1752844..1754280 + 1437 WP_004151469.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
PX704_RS08425 (1754646) 1754646..1756100 - 1455 WP_004148975.1 AMP nucleosidase -
PX704_RS08430 (1756230) 1756230..1756475 - 246 WP_023284006.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11927.87 Da        Isoelectric Point: 10.4722

>T273608 WP_023341911.1 NZ_CP118936:1752190-1752522 [Klebsiella pneumoniae subsp. pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARKGKRLERIPDVVVNEVLARLDAMLS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9442.92 Da        Isoelectric Point: 4.3566

>AT273608 WP_000288812.1 NZ_CP118936:1751932-1752189 [Klebsiella pneumoniae subsp. pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DDD0

References