Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3498378..3499031 Replicon chromosome
Accession NZ_CP118933
Organism Acinetobacter pittii strain ML4

Toxin (Protein)


Gene name cptA Uniprot ID A0A009H1K7
Locus tag PX335_RS16745 Protein ID WP_017386980.1
Coordinates 3498378..3498767 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A009HHW9
Locus tag PX335_RS16750 Protein ID WP_002117064.1
Coordinates 3498774..3499031 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX335_RS16730 (PX335_16725) 3493469..3495679 - 2211 WP_017386978.1 TRAP transporter large permease subunit -
PX335_RS16735 (PX335_16730) 3495859..3496434 - 576 WP_005078319.1 rhombosortase -
PX335_RS16740 (PX335_16735) 3496519..3497607 - 1089 WP_017386979.1 hypothetical protein -
PX335_RS16745 (PX335_16740) 3498378..3498767 - 390 WP_017386980.1 hypothetical protein Toxin
PX335_RS16750 (PX335_16745) 3498774..3499031 - 258 WP_002117064.1 succinate dehydrogenase assembly factor 2 Antitoxin
PX335_RS16755 (PX335_16750) 3499220..3500392 + 1173 WP_017386981.1 acyl-CoA dehydrogenase family protein -
PX335_RS16760 (PX335_16755) 3500443..3501933 - 1491 WP_017386982.1 NAD(P)/FAD-dependent oxidoreductase -
PX335_RS16765 (PX335_16760) 3502115..3502492 - 378 WP_002049717.1 50S ribosomal protein L17 -
PX335_RS16770 (PX335_16765) 3502511..3503518 - 1008 WP_002116730.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15509.60 Da        Isoelectric Point: 8.7390

>T273603 WP_017386980.1 NZ_CP118933:c3498767-3498378 [Acinetobacter pittii]
MIKELNFELKYSRVSVIFQLFVGLGLAILLYQLLTLIWWLCAVILLFIGSIFFLKQAQISQIEYLDQKLWSVAYFSKKEI
YRAEITKIIDYQLFVVIYFEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Download         Length: 390 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10295.73 Da        Isoelectric Point: 4.4809

>AT273603 WP_002117064.1 NZ_CP118933:c3499031-3498774 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009H1K7

Antitoxin

Source ID Structure
AlphaFold DB A0A009HHW9

References