Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4250081..4250553 Replicon chromosome
Accession NZ_CP118932
Organism Serratia marcescens strain RX11

Toxin (Protein)


Gene name relE Uniprot ID A0A6M5I1I9
Locus tag PXW05_RS20330 Protein ID WP_004937524.1
Coordinates 4250081..4250356 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PXW05_RS20335 Protein ID WP_275095170.1
Coordinates 4250362..4250553 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXW05_RS20305 (PXW05_20305) 4245400..4246680 - 1281 WP_015379029.1 polysaccharide deacetylase family protein -
PXW05_RS20310 (PXW05_20310) 4246858..4247628 - 771 WP_004937535.1 ABC transporter permease -
PXW05_RS20315 (PXW05_20315) 4247625..4248548 - 924 WP_004937534.1 ABC transporter ATP-binding protein -
PXW05_RS20320 (PXW05_20320) 4248759..4249415 + 657 WP_015379031.1 carbonate dehydratase -
PXW05_RS20325 (PXW05_20325) 4249454..4249990 - 537 WP_048234659.1 hypoxanthine phosphoribosyltransferase -
PXW05_RS20330 (PXW05_20330) 4250081..4250356 - 276 WP_004937524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PXW05_RS20335 (PXW05_20335) 4250362..4250553 - 192 WP_275095170.1 stability determinant Antitoxin
PXW05_RS20340 (PXW05_20340) 4250659..4252326 - 1668 WP_275095171.1 multicopper oxidase CueO -
PXW05_RS20345 (PXW05_20345) 4252544..4252891 + 348 WP_004937515.1 YacC family pilotin-like protein -
PXW05_RS20350 (PXW05_20350) 4253017..4253880 + 864 WP_004937512.1 polyamine aminopropyltransferase -
PXW05_RS20355 (PXW05_20355) 4253908..4254702 + 795 WP_033632106.1 adenosylmethionine decarboxylase -
PXW05_RS20360 (PXW05_20360) 4254735..4255097 - 363 WP_016930072.1 protein YacL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10378.14 Da        Isoelectric Point: 6.8785

>T273602 WP_004937524.1 NZ_CP118932:c4250356-4250081 [Serratia marcescens]
MLIVKWTDEAKTGLYTLLAFIAERNPVAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
VGVLHARQEYP

Download         Length: 276 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7219.99 Da        Isoelectric Point: 5.6492

>AT273602 WP_275095170.1 NZ_CP118932:c4250553-4250362 [Serratia marcescens]
MPTKLDPIVSEFETQEQADSYDRWFRSTVESSINSDTQRVPHDEVMAGARHIIEQAKAKRKSA

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M5I1I9

Antitoxin

Source ID Structure

References