Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3782310..3782966 Replicon chromosome
Accession NZ_CP118932
Organism Serratia marcescens strain RX11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PXW05_RS18145 Protein ID WP_021504433.1
Coordinates 3782310..3782699 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag PXW05_RS18150 Protein ID WP_004941563.1
Coordinates 3782703..3782966 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXW05_RS18130 (PXW05_18130) 3778777..3780207 + 1431 WP_275095075.1 multidrug transporter subunit MdtD -
PXW05_RS18135 (PXW05_18135) 3780204..3781586 + 1383 WP_021504432.1 two-component system sensor histidine kinase BaeS -
PXW05_RS18140 (PXW05_18140) 3781586..3782302 + 717 WP_197753782.1 two-component system response regulator BaeR -
PXW05_RS18145 (PXW05_18145) 3782310..3782699 - 390 WP_021504433.1 type II toxin-antitoxin system VapC family toxin Toxin
PXW05_RS18150 (PXW05_18150) 3782703..3782966 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PXW05_RS18155 (PXW05_18155) 3783304..3783642 + 339 WP_004941561.1 YegP family protein -
PXW05_RS18160 (PXW05_18160) 3783821..3785173 + 1353 WP_004941558.1 tRNA 5-hydroxyuridine modification protein YegQ -
PXW05_RS18165 (PXW05_18165) 3785640..3786545 + 906 WP_015378742.1 lipid kinase YegS -
PXW05_RS18170 (PXW05_18170) 3786714..3787928 + 1215 WP_275095076.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14398.63 Da        Isoelectric Point: 8.4983

>T273599 WP_021504433.1 NZ_CP118932:c3782699-3782310 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT273599 WP_004941563.1 NZ_CP118932:c3782966-3782703 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References