Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 14172..14773 Replicon chromosome
Accession NZ_CP118932
Organism Serratia marcescens strain RX11

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0Q8I8
Locus tag PXW05_RS00070 Protein ID WP_004933929.1
Coordinates 14172..14552 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag PXW05_RS00075 Protein ID WP_004933932.1
Coordinates 14552..14773 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXW05_RS00045 (PXW05_00045) 9418..10698 + 1281 WP_004933910.1 DUF3748 domain-containing protein -
PXW05_RS00050 (PXW05_00050) 10729..11076 - 348 WP_004933911.1 YceK/YidQ family lipoprotein -
PXW05_RS00055 (PXW05_00055) 11386..11799 + 414 WP_004933919.1 small heat shock chaperone IbpA -
PXW05_RS00060 (PXW05_00060) 11907..12335 + 429 WP_004933922.1 small heat shock chaperone IbpB -
PXW05_RS00065 (PXW05_00065) 12503..14161 + 1659 WP_004933926.1 putative transporter -
PXW05_RS00070 (PXW05_00070) 14172..14552 - 381 WP_004933929.1 type II toxin-antitoxin system VapC family toxin Toxin
PXW05_RS00075 (PXW05_00075) 14552..14773 - 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
PXW05_RS00080 (PXW05_00080) 14848..16098 - 1251 WP_004933935.1 valine--pyruvate transaminase -
PXW05_RS00085 (PXW05_00085) 16234..18297 - 2064 WP_275095294.1 alpha-amylase -
PXW05_RS00090 (PXW05_00090) 18494..18646 + 153 WP_015376155.1 hypothetical protein -
PXW05_RS00095 (PXW05_00095) 18648..19625 - 978 WP_033631399.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14173.48 Da        Isoelectric Point: 7.3170

>T273591 WP_004933929.1 NZ_CP118932:c14552-14172 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHTNPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT273591 WP_004933932.1 NZ_CP118932:c14773-14552 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0Q8I8

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References