Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2932131..2933959 Replicon chromosome
Accession NZ_CP118930
Organism Vibrio alginolyticus strain V208

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag O6P42_RS14335 Protein ID WP_269665188.1
Coordinates 2932131..2933492 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag O6P42_RS14340 Protein ID WP_269665189.1
Coordinates 2933477..2933959 (+) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6P42_RS14320 (O6P42_14320) 2928237..2929226 + 990 WP_269665079.1 calcium/sodium antiporter -
O6P42_RS14325 (O6P42_14325) 2929877..2930263 + 387 WP_140284002.1 transcriptional regulator -
O6P42_RS14330 (O6P42_14330) 2930868..2931650 + 783 WP_153646129.1 metallophosphoesterase -
O6P42_RS14335 (O6P42_14335) 2932131..2933492 + 1362 WP_269665188.1 type II toxin-antitoxin system HipA family toxin Toxin
O6P42_RS14340 (O6P42_14340) 2933477..2933959 + 483 WP_269665189.1 helix-turn-helix transcriptional regulator Antitoxin
O6P42_RS14345 (O6P42_14345) 2934698..2935183 + 486 WP_053302978.1 hypothetical protein -
O6P42_RS14350 (O6P42_14350) 2935867..2936430 - 564 WP_005381668.1 porin family protein -
O6P42_RS14355 (O6P42_14355) 2936831..2937712 + 882 WP_104978838.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2921608..2937712 16104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-139)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51456.17 Da        Isoelectric Point: 4.8182

>T273590 WP_269665188.1 NZ_CP118930:2932131-2933492 [Vibrio alginolyticus]
MEELTVQAFIRSEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPISFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEIADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQINEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCLDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17579.15 Da        Isoelectric Point: 10.8874

>AT273590 WP_269665189.1 NZ_CP118930:2933477-2933959 [Vibrio alginolyticus]
MGTTMNKPSNKESVQDTVARLRAKRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References