Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2622658..2624219 Replicon chromosome
Accession NZ_CP118930
Organism Vibrio alginolyticus strain V208

Toxin (Protein)


Gene name hipA Uniprot ID A0A975UC62
Locus tag O6P42_RS12855 Protein ID WP_072603483.1
Coordinates 2622658..2623986 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag O6P42_RS12860 Protein ID WP_017788886.1
Coordinates 2623980..2624219 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6P42_RS12835 (O6P42_12835) 2618304..2618768 + 465 WP_017634799.1 hotdog family protein -
O6P42_RS12840 (O6P42_12840) 2618765..2619490 + 726 WP_115385816.1 3-oxoacyl-ACP reductase FabG -
O6P42_RS12845 (O6P42_12845) 2619487..2620710 + 1224 WP_025508283.1 beta-ketoacyl-ACP synthase -
O6P42_RS12850 (O6P42_12850) 2621139..2622464 + 1326 WP_074544455.1 site-specific integrase -
O6P42_RS12855 (O6P42_12855) 2622658..2623986 - 1329 WP_072603483.1 type II toxin-antitoxin system HipA family toxin Toxin
O6P42_RS12860 (O6P42_12860) 2623980..2624219 - 240 WP_017788886.1 helix-turn-helix domain-containing protein Antitoxin
O6P42_RS12865 (O6P42_12865) 2624875..2626683 + 1809 WP_275115033.1 hypothetical protein -
O6P42_RS12870 (O6P42_12870) 2627677..2628861 - 1185 WP_275115034.1 HTH domain-containing protein -
O6P42_RS12875 (O6P42_12875) 2628967..2629158 + 192 WP_074544457.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(151-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-55)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49648.01 Da        Isoelectric Point: 9.1007

>T273589 WP_072603483.1 NZ_CP118930:c2623986-2622658 [Vibrio alginolyticus]
MVNRLHAYMNGVKVGVLEKRTNGAHVFTYDSDWVSAPNGRPISLSMPLRKGMYTGSEVINFFDNLLPDNQQIRDRIAARY
KADTKQPFDLLAKVGRDAVGAITLVPEGFDVDDHRVITAKALSEKELVRILKGYMEDAPLGMLKEEDDFRISIAGAQEKT
ALLFHDGRWMLPQGMTPTTHIIKLPIGEIVSQNNVIDLSASVDNELICMRLAKAFGIQTANCDIIRAGDVRALSVERFDR
KLSSDNSYYLRLPHEDFCQAKGIPSARKYEIDGGIGIEESIDILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSI
AASGRYQLAPLYDIISAHPLAGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFE
STARAVIDSVGNSLPTDINESVRDKIFNGVLKTVKKIQLTKK

Download         Length: 1329 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8717.96 Da        Isoelectric Point: 7.2036

>AT273589 WP_017788886.1 NZ_CP118930:c2624219-2623980 [Vibrio alginolyticus]
MLVNTPTALGNALREARKDNGLKQTDLGLRQATVSNFESNPEKSTIETLFKLLSINGLEMHIVPKGKHITETKGAVDEW

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References