273578

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3476634..3477254 Replicon chromosome
Accession NZ_CP118927
Organism Citrobacter koseri strain L2395

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag PX343_RS16615 Protein ID WP_002892050.1
Coordinates 3477036..3477254 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A8AJY4
Locus tag PX343_RS16610 Protein ID WP_012133514.1
Coordinates 3476634..3477008 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX343_RS16600 (PX343_16600) 3471770..3472963 + 1194 WP_012133512.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PX343_RS16605 (PX343_16605) 3472986..3476132 + 3147 WP_012133513.1 efflux RND transporter permease AcrB -
PX343_RS16610 (PX343_16610) 3476634..3477008 + 375 WP_012133514.1 Hha toxicity modulator TomB Antitoxin
PX343_RS16615 (PX343_16615) 3477036..3477254 + 219 WP_002892050.1 HHA domain-containing protein Toxin
PX343_RS16620 (PX343_16620) 3477438..3477989 + 552 WP_047458424.1 maltose O-acetyltransferase -
PX343_RS16625 (PX343_16625) 3478103..3478573 + 471 WP_060815856.1 YlaC family protein -
PX343_RS16630 (PX343_16630) 3478651..3478791 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
PX343_RS16635 (PX343_16635) 3478793..3479053 - 261 WP_012133519.1 type B 50S ribosomal protein L31 -
PX343_RS16640 (PX343_16640) 3479279..3480829 + 1551 WP_275055202.1 EAL domain-containing protein -
PX343_RS16645 (PX343_16645) 3480869..3481222 - 354 WP_012133521.1 DUF1428 family protein -
PX343_RS16650 (PX343_16650) 3481302..3481916 - 615 WP_112002130.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3476634..3484678 8044


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T273578 WP_002892050.1 NZ_CP118927:3477036-3477254 [Citrobacter koseri]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14437.27 Da        Isoelectric Point: 5.1444

>AT273578 WP_012133514.1 NZ_CP118927:3476634-3477008 [Citrobacter koseri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A8AJY4

References