273569

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 127126..127708 Replicon plasmid pMchErm55
Accession NZ_CP118918
Organism Mycobacteroides chelonae strain MCHL-2035

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PXJ67_RS00620 Protein ID WP_079632919.1
Coordinates 127349..127708 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0M2K7R4
Locus tag PXJ67_RS00615 Protein ID WP_046361779.1
Coordinates 127126..127362 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXJ67_RS00590 (PXJ67_00590) 122402..123052 - 651 WP_064282769.1 cutinase family protein -
PXJ67_RS00595 (PXJ67_00595) 123406..124716 - 1311 WP_064282753.1 hypothetical protein -
PXJ67_RS00600 (PXJ67_00600) 124820..125488 + 669 WP_046361780.1 TetR family transcriptional regulator -
PXJ67_RS00605 (PXJ67_00605) 125505..126368 - 864 WP_079632917.1 hypothetical protein -
PXJ67_RS00610 (PXJ67_00610) 126365..126616 - 252 WP_079632918.1 transposase -
PXJ67_RS00615 (PXJ67_00615) 127126..127362 + 237 WP_046361779.1 hypothetical protein Antitoxin
PXJ67_RS00620 (PXJ67_00620) 127349..127708 + 360 WP_079632919.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PXJ67_RS00625 (PXJ67_00625) 127622..130084 - 2463 WP_275092586.1 DEAD/DEAH box helicase -
PXJ67_RS00630 (PXJ67_00630) 130484..130969 + 486 WP_048424531.1 TIR domain-containing protein -
PXJ67_RS00635 (PXJ67_00635) 130969..131991 + 1023 WP_082164298.1 HIT domain-containing protein -
PXJ67_RS00640 (PXJ67_00640) 131967..132113 - 147 WP_275092587.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..137526 137526


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-114)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12760.69 Da        Isoelectric Point: 9.4900

>T273569 WP_079632919.1 NZ_CP118918:127349-127708 [Mycobacteroides chelonae]
MESTNPRRGELWLVAFGAGRPGEPAKHRPAVIVSADELLTGDPDPTELVVVIPVSSSRTPTSLRPPITPDEGVDTNSVAV
CRAVRGIARGRLLRHLGTLNRPTMSHIEKSVALILGLDR

Download         Length: 360 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8649.40 Da        Isoelectric Point: 4.2797

>AT273569 WP_046361779.1 NZ_CP118918:127126-127362 [Mycobacteroides chelonae]
MSTPTTTIRVPVTTRDRLNAQARDRGISVVALLDEWSHRAERDAAFAEERAATRAEAANPAVIEEDRDWEQADADGID

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2K7R4

References