273565

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1586004..1586921 Replicon chromosome
Accession NZ_CP118911
Organism Bacillus velezensis strain XRD006

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag PXG99_RS07545 Protein ID WP_007407256.1
Coordinates 1586004..1586750 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag PXG99_RS07550 Protein ID WP_003154807.1
Coordinates 1586751..1586921 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXG99_RS07525 (1581398) 1581398..1582348 - 951 WP_007610844.1 ring-cleaving dioxygenase -
PXG99_RS07530 (1582670) 1582670..1583986 + 1317 WP_007610842.1 amino acid permease -
PXG99_RS07535 (1584272) 1584272..1584889 + 618 WP_003154804.1 DUF47 domain-containing protein -
PXG99_RS07540 (1584902) 1584902..1585900 + 999 WP_003154805.1 inorganic phosphate transporter -
PXG99_RS07545 (1586004) 1586004..1586750 + 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PXG99_RS07550 (1586751) 1586751..1586921 + 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
PXG99_RS07555 (1587018) 1587018..1587143 + 126 WP_003154809.1 hypothetical protein -
PXG99_RS07560 (1587178) 1587178..1588056 - 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
PXG99_RS07565 (1588070) 1588070..1588333 - 264 WP_003154813.1 phage holin -
PXG99_RS07570 (1588347) 1588347..1588610 - 264 WP_003154815.1 hemolysin XhlA family protein -
PXG99_RS07575 (1588662) 1588662..1589423 - 762 WP_029973064.1 hypothetical protein -
PXG99_RS07580 (1589480) 1589480..1589677 - 198 WP_007610833.1 XkdX family protein -
PXG99_RS07585 (1589682) 1589682..1590107 - 426 WP_029973065.1 hypothetical protein -
PXG99_RS07590 (1590120) 1590120..1591709 - 1590 WP_029973066.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T273565 WP_007407256.1 NZ_CP118911:1586004-1586750 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT273565 WP_003154807.1 NZ_CP118911:1586751-1586921 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References