273564

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5413406..5414045 Replicon chromosome
Accession NZ_CP118910
Organism Mycobacterium marinum strain 050012

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag PQR73_RS21965 Protein ID WP_012396162.1
Coordinates 5413406..5413852 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID B2HEJ8
Locus tag PQR73_RS21970 Protein ID WP_011738542.1
Coordinates 5413857..5414045 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQR73_RS21940 (PQR73_021940) 5408581..5410101 + 1521 WP_012396157.1 carotenoid oxygenase family protein -
PQR73_RS21945 (PQR73_021945) 5410118..5410591 + 474 WP_012396158.1 VOC family protein -
PQR73_RS21950 (PQR73_021950) 5410597..5411031 - 435 WP_012396159.1 hypothetical protein -
PQR73_RS21955 (PQR73_021955) 5411102..5411875 - 774 WP_272467829.1 VOC family protein -
PQR73_RS21960 (PQR73_021960) 5412296..5413294 + 999 WP_272467828.1 EspA/EspE family type VII secretion system effector -
PQR73_RS21965 (PQR73_021965) 5413406..5413852 - 447 WP_012396162.1 SRPBCC family protein Toxin
PQR73_RS21970 (PQR73_021970) 5413857..5414045 - 189 WP_011738542.1 antitoxin Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15851.39 Da        Isoelectric Point: 8.6574

>T273564 WP_012396162.1 NZ_CP118910:c5413852-5413406 [Mycobacterium marinum]
MAKLSGSIDVPLSPDEAWMHASDLSRFKEWLTIHRVWRSTLPETLEKGAVVESIVQVKGMHNRIKWTIVRYQPPEGMTLN
GDGVGGVKVKLMAKVAAGEEGSIVSFDVHLGGPALFGPIGMVVAAALRSDINASLRNFVTVFAPSAAG

Download         Length: 447 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6586.35 Da        Isoelectric Point: 4.7205

>AT273564 WP_011738542.1 NZ_CP118910:c5414045-5413857 [Mycobacterium marinum]
MGILDKAKDLLAQNADKVETVIDKAGEFVDEKTEGKYSDTIHKVQEGAKKVAGPGAAGEQQN

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7LB02

References