Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5170784..5171409 Replicon chromosome
Accession NZ_CP118906
Organism Klebsiella pneumoniae strain T-hvKP

Toxin (Protein)


Gene name vapC Uniprot ID A0A330XB05
Locus tag PXG78_RS24895 Protein ID WP_012737091.1
Coordinates 5170784..5171167 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag PXG78_RS24900 Protein ID WP_004150355.1
Coordinates 5171167..5171409 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXG78_RS24880 (5168150) 5168150..5169052 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
PXG78_RS24885 (5169049) 5169049..5169684 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
PXG78_RS24890 (5169681) 5169681..5170610 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
PXG78_RS24895 (5170784) 5170784..5171167 - 384 WP_012737091.1 type II toxin-antitoxin system VapC family toxin Toxin
PXG78_RS24900 (5171167) 5171167..5171409 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
PXG78_RS24905 (5171614) 5171614..5172531 + 918 WP_012737090.1 alpha/beta hydrolase -
PXG78_RS24910 (5172545) 5172545..5173486 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
PXG78_RS24915 (5173531) 5173531..5173968 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
PXG78_RS24920 (5173965) 5173965..5174825 - 861 WP_004146232.1 virulence factor BrkB family protein -
PXG78_RS24925 (5174819) 5174819..5175418 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14266.53 Da        Isoelectric Point: 7.2771

>T273560 WP_012737091.1 NZ_CP118906:c5171167-5170784 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRCEAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKGFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT273560 WP_004150355.1 NZ_CP118906:c5171409-5171167 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A330XB05

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References