Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4700930..4701446 Replicon chromosome
Accession NZ_CP118906
Organism Klebsiella pneumoniae strain T-hvKP

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag PXG78_RS22650 Protein ID WP_004178374.1
Coordinates 4700930..4701214 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PXG78_RS22655 Protein ID WP_002886901.1
Coordinates 4701204..4701446 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXG78_RS22625 (4696326) 4696326..4696589 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
PXG78_RS22630 (4696719) 4696719..4696892 + 174 WP_041169004.1 hypothetical protein -
PXG78_RS22635 (4696895) 4696895..4697638 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PXG78_RS22640 (4697995) 4697995..4700133 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
PXG78_RS22645 (4700462) 4700462..4700926 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PXG78_RS22650 (4700930) 4700930..4701214 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PXG78_RS22655 (4701204) 4701204..4701446 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PXG78_RS22660 (4701524) 4701524..4703434 - 1911 WP_012737231.1 PRD domain-containing protein -
PXG78_RS22665 (4703457) 4703457..4704611 - 1155 WP_012737230.1 lactonase family protein -
PXG78_RS22670 (4704678) 4704678..4705418 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T273559 WP_004178374.1 NZ_CP118906:c4701214-4700930 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT273559 WP_002886901.1 NZ_CP118906:c4701446-4701204 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References