Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2621732..2623320 Replicon chromosome
Accession NZ_CP118906
Organism Klebsiella pneumoniae strain T-hvKP

Toxin (Protein)


Gene name hipA Uniprot ID A0A331XLA5
Locus tag PXG78_RS12760 Protein ID WP_014907613.1
Coordinates 2621732..2623054 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag PXG78_RS12765 Protein ID WP_002904790.1
Coordinates 2623054..2623320 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXG78_RS12745 (2616788) 2616788..2619289 + 2502 WP_014907611.1 fimbria/pilus outer membrane usher protein -
PXG78_RS12750 (2619277) 2619277..2620281 + 1005 WP_014907612.1 fimbrial protein -
PXG78_RS12755 (2620423) 2620423..2621715 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
PXG78_RS12760 (2621732) 2621732..2623054 - 1323 WP_014907613.1 type II toxin-antitoxin system HipA family toxin Toxin
PXG78_RS12765 (2623054) 2623054..2623320 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PXG78_RS12770 (2623558) 2623558..2623884 - 327 WP_004215084.1 hydroxyisourate hydrolase -
PXG78_RS12775 (2623881) 2623881..2624381 - 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PXG78_RS12780 (2624359) 2624359..2625738 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
PXG78_RS12785 (2626084) 2626084..2627238 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
PXG78_RS12790 (2627219) 2627219..2628142 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T273556 WP_014907613.1 NZ_CP118906:c2623054-2621732 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT273556 WP_002904790.1 NZ_CP118906:c2623320-2623054 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331XLA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References